AN EFFECTIVE ORAL MALE ANTIFERTILITY AGENT, WHICH IS BOTH NONTOXIC AND REVERSIBLE, IS NOT CURRENTLY AVAILABLE.

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1985
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
3125
Agency Tracking Number:
3125
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
763 Concord Avenue, Cambridge, MA, 02138
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
HARRY G. PARS
PRINCIPAL INVESTIGATOR
(617) 354-2800
Business Contact:
() -
Research Institute:
n/a
Abstract
AN EFFECTIVE ORAL MALE ANTIFERTILITY AGENT, WHICH IS BOTH NONTOXIC AND REVERSIBLE, IS NOT CURRENTLY AVAILABLE. GOSSYPOL, THE MOST PROMISING NONSTEROIDAL MALE ANTIFERTILITY LEAD, HAS AN UNACCEPTABLY NARROW THERAPEUTIC RATIO. WE PROPOSE THAT THE THERAPEUTIC RATIO MAY BE IMPROVED BY ALTERATION OF THE PHARMACOKINETICS AND BIOAVAILABILITY THROUGH WATER-SOLUBILIZATION. ACCORDINGLY, SEVERAL CAREFULLY CHOSEN WATER-SOLUBLE DERIVATIVES OF GOSSYPOL WILL BE PREPARED. THESE COMPOUNDS WILL THEN BE TESTED FOR BOTH IN VITRO SPERMICIDAL ACTIVITY AND IN VIVO ANTIFERTILITY ACTIVITY. THE IN VIVO TESTS WILL BE EVALUATED BOTH IN TERMS OF EFFICACY AND TOXICITY. THE IDENTIFICATION OF A COMPOUND WITH THE SAME EFFICACY AS GOSSYPOL BUT WITHOUT THE TOXIC EFFECTS WOULD PROVIDE THE BASIS FOR FURTHER STUDY LEADING TO THE EVENTUAL

* information listed above is at the time of submission.

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