IN THE THREE DAY PERIOD AFTER ONSET OF SYMPTOMS, SERIAL DETERMINATIONS OF BLOOD SERUM CPK AND LDH ISOENZYMES REMAIN THE BEST LABORATORY AID FOR EARLY DIAGNOSIS OF ACUTE MYO- CARDIAL INFARCTION.

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1986
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
4983
Agency Tracking Number:
4983
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
470 Main Road, Towaco, NJ, 07082
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
LESLIE OPPENHEIMER
PRINCIPAL INVESTIGATOR
() -
Business Contact:
() -
Research Institute:
n/a
Abstract
IN THE THREE DAY PERIOD AFTER ONSET OF SYMPTOMS, SERIAL DETERMINATIONS OF BLOOD SERUM CPK AND LDH ISOENZYMES REMAIN THE BEST LABORATORY AID FOR EARLY DIAGNOSIS OF ACUTE MYO- CARDIAL INFARCTION. THE PHASE I GOAL IS TO DEVELOP A RAPID,COST-EFFECTIVE, HIGH-PRECISION, DIAGNOSTIC ISOENZYME TEST UTILIZING HABER'S ADVANCED SEPARATION TECHNOLOGY, ELECTRO- MOLECULAR PROPULSION (EMP). IN THIS STUDY, DIFFERENT EMP MEDIA WILL BE EXAMINED FOR THEIR ABILITY TO SEPARATE CPK ANDLDH ISOENZYMES. ALSO, METHODS WILL BE DEVELOPED FOR THEIR RAPID DETECTION AND QUANTITATION. DURING PHASE II, HABER PROPOSES TO FURTHER IMPROVE AND DEVELOP THE METHODOLOGY AND TO PROTOTYPE A DIAGNOSTIC TEST FOR USE IN THE CLINICAL LABORATORY. HABER, WITH ITS ADVANCED EMP SEPARATION TECH- NOLOGY, ANTICIPATES THAT IT WILL DEVELOP A DIAGNOSTIC TEST FOR THESE ISOENZYMES WHICH WILL REQUIRE MINIMAL TECHNICAL HANDLING AND EXPERTISE AND WILL BE MORE ECONOMICAL THAN CURRENTLY USED LABORATORY TECHNIQUES.

* information listed above is at the time of submission.

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