IMMUNOASSAY FOR OSTEOCALCIN FRAGMENTS

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$46,139.00
Award Year:
1989
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Agency Tracking Number:
11116
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Haematologic Technologies Inc
57 River Rd, Box 1021, Essex Junction, VT, 05452
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
() -
Business Contact:
() -
Research Institution:
n/a
Abstract
CURRENTLY, AN ASSAY TO MEASURE THE RATE OF BONE RESORPTION IN AN EASY AND REPRODUCIBLE MANNER DOES NOT EXIST. OSTEOCALCIN, A BONE-SPECIFIC PROTEIN, IS ASSAYED AS A MARKER OF BONE FORMATION. SINCE THERE IS REASONABLE EVIDENCE THAT FRAGMENTS OF BONE PROTEINS ARE LIBERATED BY THE RESORPTIVE PROCESS, AN ASSAY OF OSTEOCALCIN FRAGMENTS SHOULD ALLOW AN ASSESSMENT OF RESORPTION. THIS, WHEN COUPLED WITH ASSESSMENTS OF FORMATION, SHOULD ALLOW AN ESTIMATION OF OSTEOPOROTIC RISK. SINCE OSTEOPOROSIS IS A MAJOR HEALTH-CARE PROBLEM OF THE ELDERLY, SUCH AN ASSESSMENT WOULD BE WIDELY APPLIED. THE SPECIFIC AIMS OF THIS PROJECT ARE: (1) THE ISOLATION AND CHARACTERIZATION OF OSTEOCALCIN FRAGMENTS FROM SERUM, (2) THE PREPARATION OF SYNTHETIC PEPTIDES AND TRYPTIC FRAGMENTS FOR USE AS ANTIGENS, AND (3) THE PREPARATION OF A PANEL OF FRAGMENT-DIRECTED MONOCLONAL ANTIBODIES THAT MAY SERVE AS REAGENTS FOR THE DEVELOPMENT OF AN OSTEOCALCIN FRAGMENT IMMUNOASSAY.

* information listed above is at the time of submission.

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