TIME-INTEGRATED MEASUREMENT OF HORMONE AVAILABILITY

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 5341
Amount: $488,000.00
Phase: Phase II
Program: SBIR
Awards Year: 1988
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Hammersmith Laboratorytorie
1720 S Marshall Road, Suite 50, Boulder, CO, 80303
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Stephen E Wade
 Principal Investigator
 (303) 499-5728
Business Contact
Phone: () -
Research Institution
N/A
Abstract
THE PURPOSE OF THIS RESEARCH IS PRODUCTION AND TESTING OF A NEEDLE-IMPLANTABLE DEVICE FOR ESTIMATING LONG-TERM TISSUE AVAILABILITY OF THE HORMONE CORTICOSTERONE IN RATS. THIS WORK CONTRIBUTES TO THE LONG-TERM GOAL OF DEVELOPING A SIMILAR DEVICE FOR MEASUREMENT OF THE TISSUE AVAILABILITY OFA BROAD RANGE OF COMPOUNDS IN BOTH RESEARCH AND MEDICAL SETTINGS. THE DEVICE OPERATES ON THE DIFFUSION-SINK PRIN- CIPLE: A COMPARTMENT IS CREATED IN WHICH THE CONCENTRATION OF THE COMPOUND OF INTEREST IS MAINTAINED AT A NEGLIGIBLE LEVEL, BY ACTION OF A BINDING PROTEIN WITH HIGH AFFINITY ANDSPECIFICITY FOR THAT COMPOUND. CONSEQUENTLY, THE COMPOUND CONTINUOUSLY DIFFUSES INTO THE DEVICE AT A RATE THAT DEPENDSON ITS AVAILABILITY IN THE IMMEDIATE ENVIRONMENT AND THE DIFFUSIVE RESISTANCE OFFERED BY THE WALLS OF THE DEVICE. BYMEASURING THE ACCUMULATION OF A COMPOUND BY A SUBCUTANEOUSLYIMPLANTED DEVICE OVER A SUITABLE TIME INTERVAL, A DIRECT ESTIMATE OF ITS TISSUE AVAILABILITY IS OBTAINED. COMPACT- NESS AND HIGH CAPACITY ARE GAINED BY USING CONCENTRATED BINDING PROTEINS PURIFIED BY AFFINITY CHROMATOGRAPHY. POTENTIAL APPLICATIONS OF THIS DEVICE INCLUDE MEASUREMENT OFTIME-INTEGRATED CORTISOL AVAILABILITY IN CLINICAL PSYCHIATRYFOR DIFFERENTIAL DIAGNOSIS OF ENDOGENOUS DEPRESSION OR MELANCHOLIA.

* information listed above is at the time of submission.

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