UNDERSTANDING THREE-DIMENSIONAL STRUCTURAL RELATIONSHIPS IN CELLS AND TISSUES IS IMPORTANT IN BOTH BASIC MEDICAL SCIENCE AND CLINICAL PATHOLOGY DIAGNOSIS.

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 3190
Amount: $49,740.00
Phase: Phase I
Program: SBIR
Awards Year: 1985
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
P. O. Box 10159, Rochester, NY, 14610
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 ROBERT D. FRANKEL
 PRINCIPAL INVESTIGATOR
 (716) 482-4070
Business Contact
Phone: () -
Research Institution
N/A
Abstract
UNDERSTANDING THREE-DIMENSIONAL STRUCTURAL RELATIONSHIPS IN CELLS AND TISSUES IS IMPORTANT IN BOTH BASIC MEDICAL SCIENCE AND CLINICAL PATHOLOGY DIAGNOSIS. TO HELP ADDRESS THIS NEED, HAMPSHIRE INSTRUMENTS IS DEVELOPING A HIGH-RESOLUTION THREE-DIMENSIONAL OPTICAL MICROSCOPY WORKSTATION WITH SIGNIFICANT COMPUTATIONAL AND INTERACTIVE GRAPHICS CAPABILITY. THIS INSTRUMENT WILL INCORPORATE THREE-DIMENSIONAL DEBLURRING ALGORITHMS USED TO SHARPEN IMAGES FROM OPTICALLY SECTIONED THICK SPECIMENS, IN BOTH ABSORPTION AND FLUORESCENCE MICROSCOPY. DURING PHASE I, 1.A MICROCOMPUTER BASED HIGH-RESOLUTION OPTICAL MICROSCOPY DEVELOPMENT SYSTEM WILL BE CONSTRUCTED; 2.THREE-DIMENSIONAL DEBLURRING ALGORITHMS FOR FLUORESCENCE AND 3.THE EFFECT OF UNAVOIDABLE PARTIAL COHERENCE OF ILLUMINATION IN HIGH-RESOLUTION MICROSCOPY ON THE VALIDITY OF THREE-DIMENSIONAL DEBLURRING ALGORITHMS WILL BE DETERMINED;4.HUMAN CANCER NUCLEI CELLS WILL BE EXAMINED TO ASSESS THE USEFULNESS OF THREE-DIMENSIONAL DEBLURRING PROCEDURES ON NUCLEAR FEATURES THAT HAVE BEEN SHOWN TO BE OF PROGNOSTIC OR DIAGNOSTIC VALUE; AND 5. HARDWARE AND SOFTWARE SPECIFICATIONS FOR PHASE II CONSTRUCTION OF THE COMMERCIAL PROTOTYPE HIGH-RESOLUTION THREE-DIMENSIONAL OPTICAL MICROSCOPY WORKSTATION WILL BE DEVELOPED.

* Information listed above is at the time of submission. *

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