UNDERSTANDING THREE-DIMENSIONAL STRUCTURAL RELATIONSHIPS IN CELLS AND TISSUES IS IMPORTANT IN BOTH BASIC MEDICAL SCIENCE AND CLINICAL PATHOLOGY DIAGNOSIS.

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$49,740.00
Award Year:
1985
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Agency Tracking Number:
3190
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Hampshire Instruments, Inc.
P. O. Box 10159, Rochester, NY, 14610
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
ROBERT D. FRANKEL
PRINCIPAL INVESTIGATOR
(716) 482-4070
Business Contact:
() -
Research Institution:
n/a
Abstract
UNDERSTANDING THREE-DIMENSIONAL STRUCTURAL RELATIONSHIPS IN CELLS AND TISSUES IS IMPORTANT IN BOTH BASIC MEDICAL SCIENCE AND CLINICAL PATHOLOGY DIAGNOSIS. TO HELP ADDRESS THIS NEED, HAMPSHIRE INSTRUMENTS IS DEVELOPING A HIGH-RESOLUTION THREE-DIMENSIONAL OPTICAL MICROSCOPY WORKSTATION WITH SIGNIFICANT COMPUTATIONAL AND INTERACTIVE GRAPHICS CAPABILITY. THIS INSTRUMENT WILL INCORPORATE THREE-DIMENSIONAL DEBLURRING ALGORITHMS USED TO SHARPEN IMAGES FROM OPTICALLY SECTIONED THICK SPECIMENS, IN BOTH ABSORPTION AND FLUORESCENCE MICROSCOPY. DURING PHASE I, 1.A MICROCOMPUTER BASED HIGH-RESOLUTION OPTICAL MICROSCOPY DEVELOPMENT SYSTEM WILL BE CONSTRUCTED; 2.THREE-DIMENSIONAL DEBLURRING ALGORITHMS FOR FLUORESCENCE AND 3.THE EFFECT OF UNAVOIDABLE PARTIAL COHERENCE OF ILLUMINATION IN HIGH-RESOLUTION MICROSCOPY ON THE VALIDITY OF THREE-DIMENSIONAL DEBLURRING ALGORITHMS WILL BE DETERMINED;4.HUMAN CANCER NUCLEI CELLS WILL BE EXAMINED TO ASSESS THE USEFULNESS OF THREE-DIMENSIONAL DEBLURRING PROCEDURES ON NUCLEAR FEATURES THAT HAVE BEEN SHOWN TO BE OF PROGNOSTIC OR DIAGNOSTIC VALUE; AND 5. HARDWARE AND SOFTWARE SPECIFICATIONS FOR PHASE II CONSTRUCTION OF THE COMMERCIAL PROTOTYPE HIGH-RESOLUTION THREE-DIMENSIONAL OPTICAL MICROSCOPY WORKSTATION WILL BE DEVELOPED.

* information listed above is at the time of submission.

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