PRODUCTION OF DENQUE 2 ENVELOP PROTEIN IN THE YEAST SACCHAROMYCES CEREVISIAE

Award Information
Agency:
Department of Defense
Branch
Army
Amount:
$571,526.00
Award Year:
1991
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Award Id:
9775
Agency Tracking Number:
9775
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
99-193 Aiea Heights Dr, Aiea, HI, 96701
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Dr John M Ivy
(808) 486-5380
Business Contact:
() -
Research Institution:
n/a
Abstract
THE FOUR SEROTYPES OF DENGUE VIRUSES ARE A LEADING CAUSE OF MORBIDITY THROUGHOUT THE TROPICS AND SUBTROPICS. FOR USE IN DIAGNOSTICS AND IN SUBUNIT VACCINES AGAINST DENGUE, A RELIABLE AND INEXPENSIVE SOURCE OF DENGUE ANTIGENS IS REQUIRED. FOR THESE PURPOSES, EXPRESSION OF RECOMBINANT ANTIGENS IN MICROORGANISMS IS BEST SUITED. WE PROPOSE TO USE THE YEAST SACCHAROMYCES CEREVISIAE TO PRODUCE THE DENGUE 2 VIRUS ENVELOPE GLYCOPROTEIN. THE SEQUENCES ENCODING THE ENVELOP PROTEIN WILL BE PLACED UNDER THE TRANSCRIPTIONAL CONTROL OF BOTH A CONSTITUTIVE AND A REGULATED PROMOTER, WITH AND WITHOUT SECRETION SIGNAL PEPTIDES. RELATIVE AMOUNTS OF ANTIGENIC MATERIAL WILL BE DETERMINED FOR EACH SYSTEM.

* information listed above is at the time of submission.

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