PALYTOXIN PRODRUG ACTIVATION BY ANTIBODY-LINKED ENZYME

Award Information
Agency:
Department of Health and Human Services
Amount:
$459,212.00
Program:
SBIR
Contract:
N/A
Solitcitation Year:
N/A
Solicitation Number:
N/A
Branch:
N/A
Award Year:
1992
Phase:
Phase II
Agency Tracking Number:
16417
Solicitation Topic Code:
N/A
Small Business Information
Hawaii Biotechnology Group, In
99-193 Aiea Heights Drive, Aiea, HI, 96701
Hubzone Owned:
N
Woman Owned:
N
Socially and Economically Disadvantaged:
N
Duns:
N/A
Principal Investigator
 Bignami, Gary S
 Principal Investigator
 (808) 486-5397
Business Contact
 1 R43 CA54652-01
Phone: () -
Research Institution
N/A
Abstract
PALYTOXIN IS AN EXTREMELY CYTOTOXIC LOW MOLECULAR WEIGHT NATURAL PRODUCT ISOLATED FROM SOFT CORALS OF THE GENUS, PALYTHOA. N-ACYLATED DERIVATIVES OF PALYTOXIN HAVE BEEN REPORTED TO BE UP TO 100-FOLD LESS CYTOTOXIC THAN THE UNMODIFIED TOXIN. PALYTOXIN N-ACYL DERIVATIVES WHICH CAN BE CONVERTED TO THE NATIVE TOXIN BY ANTITUMOR MONOCLONAL ANTIBODY- ENZYME CONJUGATES WILL BE PREPARED AND TESTED FOR ANTIGEN-SELECTIVE CYTOTOXICITY AGAINST CELLS IN CULTURE.

* information listed above is at the time of submission.

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