POLIO/DENGUE CHIMERAE FOR DENGUE VACCINE DEVELOPMENT

Award Information

Agency: Department of Health and Human Services

Branch: N/A

Contract: N/A

Agency Tracking Number: 18957

Amount: $50,000.00

Phase: Phase I

Program: SBIR

Solicitation Topic Code: N/A

Solicitation Number: N/A

Timeline

Solicitation Year: N/A

Award Year: 1992

Award Start Date (Proposal Award Date): N/A

Award End Date (Contract End Date): N/A

Small Business Information

HAWAII BIOTECH, INC.

99-193 Aiea Heights Drive

Aiea, HI 96701

United States

DUNS: N/A

HUBZone Owned: No

Woman Owned: No

Socially and Economically Disadvantaged: No

Principal Investigator

Name: Eileen T Nakano
Phone: (808) 486-5333

Business Contact

Phone: () -

Research Institution

N/A

Abstract

WE WILL CONSTRUCT HYBRID POLIO/DENGUE VIRUS GENOMES IN ORDER TO DEVELOP A VACCINE FOR DENGUE VIRUS. IN THE CHIMERIC GENOMES, ONE OF TWO DENGUE VIRUS ENVELOPE GENE FRAGMENTS WILL REPLACE SEGMENT OF THE POLIO VIRUS STRUCTURAL PROTEIN GENES. SUCH CHIMERAE WOULD HAVE THE ABILITY TO REPLICATE IN THE GUT AND TO PRODUCE LARGE QUANTITIES OF IMMUNOGEN WITHOUT INFECTIOUS PARTICLE FORMATION, UNLIKE ATTENUATED LIVE VACCINES OR RECOMBINANT VIRUS VECTORS. PHASE II RESEARCH WILL INCLUDE THE DETERMINATION OF THESE CHIMERIC GENOMES' ABILITY TO ELICIT A PROTECTIVE IMMUNERESPONSE IN MICE, THE CONSTRUCTION AND EVALUATION OF ADDITIONAL CHIMERIC GENOMES, AND THE EXPLORATION INTO PRODUCTION METHODS FOR ENCAPSULATED POLIO/DENGUE GENOMES IN THE ABSENCE OF HELPER VIRUS.

* Information listed above is at the time of submission. *

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POLIO/DENGUE CHIMERAE FOR DENGUE VACCINE DEVELOPMENT