POLIO/DENGUE CHIMERAE FOR DENGUE VACCINE DEVELOPMENT

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1992
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Agency Tracking Number:
18957
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Hawaii Biotechnology Group Inc
99-193 Aiea Heights Drive, Aiea, HI, 96701
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Eileen T Nakano
(808) 486-5333
Business Contact:
() -
Research Institution:
n/a
Abstract
WE WILL CONSTRUCT HYBRID POLIO/DENGUE VIRUS GENOMES IN ORDER TO DEVELOP A VACCINE FOR DENGUE VIRUS. IN THE CHIMERIC GENOMES, ONE OF TWO DENGUE VIRUS ENVELOPE GENE FRAGMENTS WILL REPLACE SEGMENT OF THE POLIO VIRUS STRUCTURAL PROTEIN GENES. SUCH CHIMERAE WOULD HAVE THE ABILITY TO REPLICATE IN THE GUT AND TO PRODUCE LARGE QUANTITIES OF IMMUNOGEN WITHOUT INFECTIOUS PARTICLE FORMATION, UNLIKE ATTENUATED LIVE VACCINES OR RECOMBINANT VIRUS VECTORS. PHASE II RESEARCH WILL INCLUDE THE DETERMINATION OF THESE CHIMERIC GENOMES' ABILITY TO ELICIT A PROTECTIVE IMMUNERESPONSE IN MICE, THE CONSTRUCTION AND EVALUATION OF ADDITIONAL CHIMERIC GENOMES, AND THE EXPLORATION INTO PRODUCTION METHODS FOR ENCAPSULATED POLIO/DENGUE GENOMES IN THE ABSENCE OF HELPER VIRUS.

* information listed above is at the time of submission.

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