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BISPECIFIC ANTIBODY FOR DIRECTED DELIVERY OF TAXOL
Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 19070
Amount:
$50,000.00
Phase:
Phase I
Program:
SBIR
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Timeline
Solicitation Year:
N/A
Award Year:
1992
Award Start Date (Proposal Award Date):
N/A
Award End Date (Contract End Date):
N/A
Small Business Information
99-193 Aiea Heights Drive
Aiea, HI
96701
United States
DUNS:
N/A
HUBZone Owned:
No
Woman Owned:
No
Socially and Economically Disadvantaged:
No
Principal Investigator
Name: Gary S Bignami
Phone: (808) 486-5333
Phone: (808) 486-5333
Business Contact
Phone: () -
Research Institution
N/A
Abstract
WE WILL ACHIEVE THE SELECTIVE DELIVERY OF CYTOTOXIC AGENTS THROUGH THE USE OF BISPECIFIC ANTIBODIES. TAXOL IS A PROMISING NEW ANTICANCER AGENT ISOLATED IN LOW YIELD FROM THE BARK OF THE PACIFIC YEW TREE, TAXUS BREVIFOLIA. THE APPLICANT WILL PREPARE A THIOETHER-LINKED BISPECIFIC ANTIBODY WITH DIAL SPECIFICITY FOR TAXOL AND HUMAN CANCER CELLS. IT IS ASSERTED THAT THIS BISPECIFIC ANTIBODY WILL POTENTIATE THE ACTION OF TAXOL IN TARGET TISSUE, MINIMIZE SIDE-EFFECTS, AND REDUCE THE TOTAL AMOUNT OF TAXOL REQUIRED FOR EFFECTIVE THERAPY.
* Information listed above is at the time of submission. *
