BISPECIFIC ANTIBODY FOR DIRECTED DELIVERY OF TAXOL

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1992
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Agency Tracking Number:
19070
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Hawaii Biotechnology Group Inc
99-193 Aiea Heights Drive, Aiea, HI, 96701
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Gary S Bignami
(808) 486-5333
Business Contact:
() -
Research Institution:
n/a
Abstract
WE WILL ACHIEVE THE SELECTIVE DELIVERY OF CYTOTOXIC AGENTS THROUGH THE USE OF BISPECIFIC ANTIBODIES. TAXOL IS A PROMISING NEW ANTICANCER AGENT ISOLATED IN LOW YIELD FROM THE BARK OF THE PACIFIC YEW TREE, TAXUS BREVIFOLIA. THE APPLICANT WILL PREPARE A THIOETHER-LINKED BISPECIFIC ANTIBODY WITH DIAL SPECIFICITY FOR TAXOL AND HUMAN CANCER CELLS. IT IS ASSERTED THAT THIS BISPECIFIC ANTIBODY WILL POTENTIATE THE ACTION OF TAXOL IN TARGET TISSUE, MINIMIZE SIDE-EFFECTS, AND REDUCE THE TOTAL AMOUNT OF TAXOL REQUIRED FOR EFFECTIVE THERAPY.

* information listed above is at the time of submission.

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