Synthesis of a Taxol-Cehalosporin Prodrug

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 21988
Amount: $50,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1993
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Hawaii Biotechnology Group,
99-193 Aiea Heights Drive, Aiea, HI, 96701
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Sean O'Malley
 (808) 486-5333
Business Contact
Phone: () -
Research Institution
N/A
Abstract
A Taxol prodrug derivative will be prepared. This compound will be tested for its differential cytotoxicity compared to Taxol and for its ability to be enzymatically activated. The cytotoxicity of the prodrug in combination with a monoclonal-antibody enzyme conjugate in the presence of targeted and non-targeted cells will also be examined.

* information listed above is at the time of submission.

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