Neutralizing Monoclonal Antibodies to Maitotoxin

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$80,250.00
Award Year:
1994
Program:
SBIR
Phase:
Phase I
Contract:
1 R43 ES06863-1,
Award Id:
25053
Agency Tracking Number:
25053
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
99-193 Aiea Heights Drive, Aiea, HI, 96701
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Gary Bignami
(808) 486-5333
Business Contact:
() -
Research Institute:
n/a
Abstract
Murine monoclonal antibodies which neutralize maitotoxin will be selected using a functionalassay that exploits the hemolytic action of maitotoxin. The resulting antibodies should be useful forseveral purposes. They will provide a means to measure the toxin content in crude extracts of fishtissues or dinoflagellate cultures by hemolysis neutralization assay. More importantly, neutralizingmonoclonal antibodies may provide a means to passively protect or reverse maitotoxin poisoning. Suchreagents could be humanized for clinical therapeutic applications. The antibodies may also be useful forother purposes including, studying the receptor pharmacology of maitotoxin and calcium ion channels;identifying and isolating maitotoxin-producing dinoflagellates; and, isolating purified maitotoxin byimmunoaffinity chromatography. Anti-idiotypic antibodies of those which neutralize maitotoxin shouldalso be of interest for a variety of analytical and biomedical applications.

* information listed above is at the time of submission.

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