Neutralizing Monoclonal Antibodies to Maitotoxin

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1 R43 ES06863-1,
Agency Tracking Number: 25053
Amount: $80,250.00
Phase: Phase I
Program: SBIR
Awards Year: 1994
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
99-193 Aiea Heights Drive, Aiea, HI, 96701
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Gary Bignami
 (808) 486-5333
Business Contact
Phone: () -
Research Institution
N/A
Abstract
Murine monoclonal antibodies which neutralize maitotoxin will be selected using a functionalassay that exploits the hemolytic action of maitotoxin. The resulting antibodies should be useful forseveral purposes. They will provide a means to measure the toxin content in crude extracts of fishtissues or dinoflagellate cultures by hemolysis neutralization assay. More importantly, neutralizingmonoclonal antibodies may provide a means to passively protect or reverse maitotoxin poisoning. Suchreagents could be humanized for clinical therapeutic applications. The antibodies may also be useful forother purposes including, studying the receptor pharmacology of maitotoxin and calcium ion channels;identifying and isolating maitotoxin-producing dinoflagellates; and, isolating purified maitotoxin byimmunoaffinity chromatography. Anti-idiotypic antibodies of those which neutralize maitotoxin shouldalso be of interest for a variety of analytical and biomedical applications.

* Information listed above is at the time of submission. *

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