You are here

Expression of Antibodies in Neurospora

Award Information
Agency: Department of Defense
Branch: Army
Contract: N/A
Agency Tracking Number: 26303
Amount: $66,474.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Solicitation Year: N/A
Award Year: 1994
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
99-193 Aiea Heights Drive
Aiea, HI 96701
United States
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 John Marshall Ivy, Ph.d.
 (808) 486-5333
Business Contact
Phone: () -
Research Institution

The filamentous fungi, owing to their ability to secrete high levels of proteins, are attractive organisms for the expression and secretion of heterologous proteins of commercial and medical value. Secretion is a key element in their attraction, for secretion enables proper folding and processing of complex proteins and facilitates their purification. Proper folding and processing, simplified purification, and inexpensive culturing will translate into less expensive production. We have demonstrated secretion and processing of an enzymatically active mammalian protein, bovine preprochymosin, from "Neurospora crassa." In the proposed Phase I effort, we will test the feasibility of expressing in "Neurospora" a single chain antibody fragment (scFv) of established medical value and determine the ability of the recombinant scFv to recognize tumor cell surface antigen.

* Information listed above is at the time of submission. *

US Flag An Official Website of the United States Government