Synthetic Receptor Libraries for Small Organic Molecules

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1 R43 CA68893-01,
Agency Tracking Number: 29259
Amount: $100,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1995
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Hawaii Biotechnology Group,
99-193 Aiea Heights Drive, Aiea, HI, 96701
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Paul Grothaus
 () -
Business Contact
Phone: () -
Research Institution
N/A
Abstract
We will develop high affinity, highly selective, synthetic receptors for small organic molecules. Achemistry approach will be used to produce an encoded, highly diverse, novel type of receptor librarconsists of three peptide arms symmetrically arranged about a rigid hydrophobic pocket. This librarythe ability to bind to a wide variety of target molecules in a wide variety of solvent systemss of iwould serve as substitutes for monoclonal antibodies in affinity chromatography, ELISA assays, and bAs a test case of this idea, we will screen the encoded library for receptors which selectively bindbaccatin III. Selected receptors will be resynthesized and further characterized.

* information listed above is at the time of submission.

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