EVALUATION OF IMMUNOGENICITY : MALARIA SUBUNIT VACCINE

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R43AI051021-01
Agency Tracking Number: AI051021
Amount: $129,871.00
Phase: Phase I
Program: SBIR
Awards Year: 2002
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
HAWAII BIOTECH, INC., 99-193 AIEA HEIGHTS DR, STE 236, AIEA, HI, 96701
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 DAVID CLEMENTS
 (808) 486-5333
 STAFF@HIBIOTECH.COM
Business Contact
 TOM HUMPHREYS
Phone: (808) 486-5333
Email: STAFF@HIBIOTECH.COM
Research Institution
N/A
Abstract
Malaria is a tropical parasitic disease that poses a significant health threat to much of the world. Each year, approximately 500 million become infected and more them 2 million die. There is great need to control the spread of the disease. One of the main focuses of malaria vaccine development has been on the use of recombinant proteins derived from the various developmental stages of the parasite. The goal of the proposed research is to enhance the immune response to MSP-1C- terminal subunits. Several clinically relevant adjuvants will be evaluated for the ability to elicit an appropriate immune response when combined with an MSP-1 p42 subunit. Additionally, the p42 subunit will be reengineered to contain conserved T-cell epitopes in an effort to focus the antibody response to the conserved p19 region. The ability to identify adjuvant formations that can potentiate an effective immune response to the MSP-1 p42 antigen and/or the ability to enhance the immune response to p19 by improved subunit design would facilitate the development of MSP-1 C-terminal subunits into viable malaria vaccine products.

* Information listed above is at the time of submission. *

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