EVALUATION OF IMMUNOGENICITY : MALARIA SUBUNIT VACCINE

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$129,871.00
Award Year:
2002
Program:
SBIR
Phase:
Phase I
Contract:
1R43AI051021-01
Award Id:
60454
Agency Tracking Number:
AI051021
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
HAWAII BIOTECH, INC., 99-193 AIEA HEIGHTS DR, STE 236, AIEA, HI, 96701
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
DAVID CLEMENTS
(808) 486-5333
STAFF@HIBIOTECH.COM
Business Contact:
TOM HUMPHREYS
(808) 486-5333
STAFF@HIBIOTECH.COM
Research Institute:
n/a
Abstract
Malaria is a tropical parasitic disease that poses a significant health threat to much of the world. Each year, approximately 500 million become infected and more them 2 million die. There is great need to control the spread of the disease. One of the main focuses of malaria vaccine development has been on the use of recombinant proteins derived from the various developmental stages of the parasite. The goal of the proposed research is to enhance the immune response to MSP-1C- terminal subunits. Several clinically relevant adjuvants will be evaluated for the ability to elicit an appropriate immune response when combined with an MSP-1 p42 subunit. Additionally, the p42 subunit will be reengineered to contain conserved T-cell epitopes in an effort to focus the antibody response to the conserved p19 region. The ability to identify adjuvant formations that can potentiate an effective immune response to the MSP-1 p42 antigen and/or the ability to enhance the immune response to p19 by improved subunit design would facilitate the development of MSP-1 C-terminal subunits into viable malaria vaccine products.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government