PHASE I SAR ESTIMATION OF SKIN AND EYE IRRITATION

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$450,000.00
Award Year:
1985
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Agency Tracking Number:
433
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Health Designs Inc.
183 Main Street, Rochester, NY, 14604
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Kurt Enslein
(716) 546-1464
Business Contact:
() -
Research Institution:
n/a
Abstract
THIS PROPOSAL DEALS WITH THE DEVELOPMENTOF STRUCTURE ACTIVITY EQUATIONS (MODELS) FOR THE DRAIZE SKIN AND EYE IRRITANCY TESTS. THE APPLICANT HAS PREVIOUSLY DEVELOPED SUCH MODELS FOR RAT ORAL LD(50), MUTAGENICITY, CARCINOGENICITY, TERATOGENICITY, AND BIODEGRADABILITY. THE PRINCIPLES USED IN THE DEVELOPMENT OF THESE MODELS ARE TO BE APPLIED TO THE DEVELOPMENT OF SIMILAR MODELS FOR THE DRAIZE TESTS. IN THESE MODELS A SET OF CHEMICALS FOR WHICH THE ENDPOINTS HAVE BEEN MEASURED ARE USED TO FORM THE BASIS OF REGRESSION EQUATIONS. THE INDEPENDENT PARAMETERS INCLUDESUBSTRUCTURAL FRAGMENTS, AND PHYSICAL PARAMETERS SUCH AS OCTANOL-WATER PARTITION COEFFICIENT, MOLECULAR WEIGHT, MOLECULAR AREA AND VOLUME, MOLECULAR CONNECTIVITY INDICES, ETC. THE MAJORITY OF THE DATA FOR THE MODEL WILL BE DERIVEDFROM RTECS (REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES), WITH THE REMAINING DATA BEING OBTAINED FROM THEU. S. ARMY AND A DIRECETED SURVEY OF THE LITERATURE.

* information listed above is at the time of submission.

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