SAR ESTIMATION OF CARCINOGENESIS BIOASSAY RESULTS.

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 1397
Amount: $249,000.00
Phase: Phase II
Program: SBIR
Awards Year: 1987
Solitcitation Year: N/A
Solitcitation Topic Code: N/A
Solitcitation Number: N/A
Small Business Information
Health Designs Inc.
183 Main Street East, Rochester, NY, 14604
Duns: N/A
Hubzone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Kurt Enslein
 President
 () -
Business Contact
Phone: () -
Research Institution
N/A
Abstract
THE PURPOSE OF THIS APPLICATION IS TO DEVELOP STRUCTURE-ACTIVITY MODELS OF THE NCI/NTP AND OTHER CARCINOGENESIS BLOASSAYS. THROUGH THESE MODELS IT WOULD BECOME POSSIBLE TO PREDICT THE PROBABILITY OF CARCINOGENICITY OF UNTESTED COMPOUNDS. THE APPLICATION WOULD BE TO THOSE CHEMICALS THAT HAVE NOT AS YET AND PROBABLY NEVER WILL BE TESTED ALREADY IN CURRENT COMMERCE, AS WELL AS THOSE BEING INTRODUCED AT THE RATE OF APPROXIMATELY 1,000 PER YEAR INTO COMMERCE. OTHER APPLICATIONS EXIST AT THE DEVELOPMENTAL STAGE TO ENHANCE THE SAFETY OF LABORATORY AND PRODUCTION PERSONNEL, AND TO MINIMIZE THE USE OF ANIMALS IN RESEARCH AND TESTING. DURING PHASE I IT IS EXPECTED THAT THE FEASIBILITY OF THIS APPROACH CAN BE DEMONSTRATED. DURING PHASE II A REFINEMENT OF THE APPROACH AND COMMERCIALIZATION WOULD BE EXPECTED. THE METHODOLOGY PROPOSED IN THIS APPLICATION CONSISTS MOSTLY OF COLLECTION OF RESULTS OF CARCINOGENESIS BIOASSAYS, THEIR CRITICAL EVALUATION, AND MODELLING OF THE ASSEMBLED DATA BASES BY MEANS OF CONVENTIONAL MULTIVARIATE STATISTICAL METHODOLOGY. THE TECHNOLOGICAL INNOVATIONS EXPECTED FROM THIS PROJECT WOULD BE THE ABILITY TO PREDICT WHICH CHEMICALS ARE LIKELY TO BE CARCINOGENS ON THE BASIS OF STRUCTURE-ACTIVITY EQUATIONS TO A DEGREE NOT HERETOFORE POSSIBLE. THE COMMERCIAL APPLICATIONS WOULD BE TO THOSE COMPOUNDS IN THE TOXIC SUBSTANCES CONTROL ACT INVENTORY WHICH HAVE NOT BEEN TESTED, TO CHEMICALS CURRENTLY BEING DEVELOPED, AND AS A TOOL IN ITS SOFTWARE IMPLEMENTATION. THIS APPLICATION MAY BE OF PARTICULAR INTEREST TO THE DIVISION OF RESEARCH RESOURCES.

* information listed above is at the time of submission.

Agency Micro-sites

US Flag An Official Website of the United States Government