INVESTIGATION OF 3-DIMENSIONAL PARAMETERS FOR SAR MODELLING OF MUTAGENICITY

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1988
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Agency Tracking Number:
8121
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Health Designs Inc
183 Main St E, Rochester, NY, 14604
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
() -
Business Contact:
() -
Research Institution:
n/a
Abstract
IN THIS RESEARCH WE WILL INVESTIGATE THE APPLICABILITY OF 3-DIMENSIONAL PARAMETERS TO THE STRUCTURE-ACTIVITY MODELLINGOF MUTAGENICITY. THE MUTAGENIC ENDPOINTS WILL BE THE AMES TEST, AND EITHER THE MOUSE LYMPHOMA OR THE SYRIAN HAMSTER OVARY CELL ASSAY. THE PARAMETERS TO BE INVESTIGATED WILL INCLUDE POLARIZABILITY, ELECTRONIC CHARGES, MOMENTS OF INERTIA AND FUNCTIONS OF THESE, AREA, VOLUME, AND MOLECULAR CROSS-SECTIONAL AREA.

* information listed above is at the time of submission.

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