CYSTIC FIBROSIS (CF) IS A LETHAL AUTOSOMAL RECESSIVE DISEASEAFFECTING MAINLY WHITE CHILDREN.

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1986
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
4881
Agency Tracking Number:
4881
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
4202 Gardendale, Suite 102, San Antonio, TX, 28229
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
BETTY J DABNEY
PRINCIPAL INVESTIGATOR
(512) 690-9984
Business Contact:
() -
Research Institution:
n/a
Abstract
CYSTIC FIBROSIS (CF) IS A LETHAL AUTOSOMAL RECESSIVE DISEASEAFFECTING MAINLY WHITE CHILDREN. THE RISK OF BEING A CARRIER OF THE CYSTIC FIBROSIS GENE IN THE WHITE POPULATION IS HIGH-APPROXIMATELY 5%. AFFECTED INDIVIDUALS WITH CYSTIC FIBROSIS CAN BE DIAGNOSED BY HIGH SWEAT CHLORIDE LEVELS WITHAPPROXIMATELY 98% RELIABILITY. HOWEVER, THOSE INDIVIDUALS WHO CARRY A SINGLE CYSTIC FIBROSIS GENE AND ARE POTENTIAL PARENTS OF CYSTIC FIBROSIS CHILDREN CANNOT BE DIAGNOSED. FOR EXAMPLE, NORMAL SIBLINGS OF CYSTIC FIBROSIS PATIENTS HAVE A 66.6% CHANCE OF CARRYING ONE OF THE DEFECTIVE GENES LEADING TO CYSTIC FIBROSIS. SUCH INDIVIDUALS AND OTHERS AREINTERESTED IN A DIAGNOSTIC TEST FOR DETECTING THE CYSTIC FIBROSIS GENE. THE COMMERCIAL APPLICATION OF DNA TECHNOLOGYTOWARD DEVELOPING A COMMERCIAL TEST FOR THE CYSTIC FIBROSIS GENE WILL BE THE LONG-TERM OBJECTIVE OF THIS PROJECT. PHASEI OF THIS PROJECT WILL IDENTIFY ONE OR MORE DNA POLYMORPH- ISMS THAT COSEGREGATE WITH THE CYSTIC FIBROSIS GENE BACAUSE OF THEIR PROXIMITY TO THE GENE ON A HUMAN CHROMOSOME. IDENTIFICATION OF SUITABLE DMA POLYMORPHISMS WILL BE USED TOSTUDY THE FEASIBILITY OF DETECTING THE SEGREGATION OF THE CFGENE IN FAMILIES FROM TEXAS, NEW YORK, AND MEXICO.

* information listed above is at the time of submission.

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