EFFECTS OF A BLOOD CELL GROWTH FACTOR

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$500,000.00
Award Year:
1992
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Agency Tracking Number:
11128
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Hipple Cancer Research Center
4100 S Kettering Blvd, Dayton, OH, 45439
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
() -
Business Contact:
() -
Research Institution:
n/a
Abstract
THE HEMATOPOIETIC ACTIVITIES OF CORDYCEPS SINENSIS (CS), A RARE CHINESE FUNGUS, ARE KNOWN. RECENTLY, CS HAS BEEN SHOWN TO HAVE ADJUVANT EFFECTS WHEN ADMINISTERED TO PATIENTS WITH HEMATOLOGIC DISEASES AND TO CANCER PATIENTS DURING OR AFTER CHEMOTHERAPY OR RADIOTHERAPY. CS HAS BEEN SHOWN TO HAVE MULTIPLE BIOLOGICAL ACTIVITIES INCLUDING ENHANCEMENT OF IL-2 AND HEMATOPOIETIC GROWTH FACTOR PRODUCTION, AND STIMULATION OF NATURAL KILLER CELLS AND MACROPHAGES. THESE RESULTS SUGGEST THAT CS POSSESSES HEMATOPOIETIC STIMULATIVE OR IMMUNOPOTENTIATING FUNCTIONS. THE HIPPLE CANCER RESEARCH CORPORATION HAS OBTAINED QUANTITIES OF THIS NATIVE CHINESE MEDICINAL FUNGUS SUFFICIENT FOR IN VITRO EVALUATION OF ITS IMMUNOHEMATOLOGICAL AND ADJUVANT EFFECTS ON HUMAN CELLS. IN PHASE I, FRACTIONS OF CS WILL BE SCREENED FOR ACTIVITY IN IN VITRO HEMATOPOIETIC AND IMMUNOLOGIC ASSAYS USING HUMAN BONE MARROW OR PERIPHERAL BLOOD CELLS. THE EFFECTS OF CS FRACTIONS ON THE EXPRESSION OF HEMATOPOIETIC GROWTH FACTORS AND CYTOKINES WILL BE DETERMINED. IN PHASE II, CS COMPONENTS FOUND TO BE ACTIVE WILL BE PURIFIED TO HOMOGENEITY, ANALYZED BIOCHEMICALLY, AND EVALUATED QUANTITATIVELY IN APPROPRIATE HEMATOPOIETIC AND IMMUNOLOGICAL ASSAYS. IF FOUND TO SHOW SUFFICIENT PROMISE, THE GENES CODING THE ACTIVE COMPONENTS WILL BE CLONED FOR RECOMBINANT DNA PRODUCTION.

* information listed above is at the time of submission.

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