ADAPTION OF CAPSCAN TECHNOLOGY TO HEMATOPOIETIC ASSAYS

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$500,000.00
Award Year:
1993
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Award Id:
19094
Agency Tracking Number:
19094
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
4100 South Kettering Boulevard, Dayton, OH, 45439
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Martin J Murphy Jr
(513) 299-7120
Business Contact:
() -
Research Institute:
n/a
Abstract
THE HIPPLE CANCER RESEARCH CORPORATION DEVELOPED PATENTED TECHNOLOGY (CAPSCAN TM) FOR QUANTITATING PARTICLES INSIDE MICROCAPILLARY TUBES, INCLUDING TUMOR CELL COLONIES. HIPPLE ALSO PIONEERED MICROCAPILLARY-BASED HEMATOPOIETIC ASSAYS FOR HUMAN MYELOTOXICITY TESTING OF INVESTIGATIONAL AGENTS. AUTOMATED COLONY COUNTING WOULD FACILITATE FASTER AND LESS EXPENSIVE MYELOTOXICITY EVALUATIONS, KEEPING PACE WITH MODERN EFFICACY SCREENS (I.E., IN VITRO CANCER CELL LINE PANELS), SO THAT NEW ANTI-CANCER AND ANTI-HIV AGENTS WITH FAVORABLE THERAPEUTIC INDICES, RATHER THAN EFFICACIES, WOULD BE SELECTED FOR DEVELOPMENT. IN PHASE I, WE WILL DETERMINE THE FEASIBILITY OF ADAPTING CAP SCAN TM TECHNOLOGIES TO AUTOMATED QUANTITATION OF COLONIES OF HUMAN HEMATOPOIETIC PROGENITORS (CFU-GM AND BFU-E). IN PHASE II, WE WILL DEVELOP THE REQUIRED SOFTWARE AND HARDWARE ADAPTATIONS INDICATED BY THE PHASE I RESEARCH, AND EXTEND THE AUTOMATION TO MURINE HEMATOPOIETIC COLONIES AND TO HEMATOPOIETIC COLONIES THAT REQUIRE SPECIAL STAINS FOR DETECTION (CFU-MEG). IF SUCCESSFUL, THIS WOULD MARK THE FIRST TECHNOLOGY DEVELOPED FOR AUTOMATED COUNTING OF HEMATOPOIETIC COLONIES. WITH OVER 10,000 COMPOUNDS SCREENED EACH YEAR IN ANTI-CANCER DRUG DISCOVERY PROGRAMS, IT IS OBVIOUS THAT THERE ARE NUMEROUS OPPORTUNITIES FOR COMMERCIAL APPLICATION OF THIS TECHNOLOGY.

* information listed above is at the time of submission.

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