AMYLASE ISOZYME DETERMINATION WITH MONOCLONAL ANTIBODIES

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 2997
Amount: $188,000.00
Phase: Phase II
Program: SBIR
Awards Year: 1987
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
1500 Avon St. Ext., Charlottesville, VA, 22901
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Michael P. Woodward
 Principal Investigator
 (804) 295-5912
Business Contact
Phone: () -
Research Institution
N/A
Abstract
THE ULTIMATE GOAL OF THIS RESEARCH IS TO DEVELOP A DIAGNOSTIC KIT WHICH WILL PERMIT EASY AND RAPID IDENTIFICATION OF OVARIAN AMYLASE. THIS AMYLASE ISOZYME APPEARS TO BE A GOOD INDICATOR FOR OVARIAN CANCER. IN ADDITION, MONOCLONAL ANTIBODIES WILL BE PRODUCED WHICH WILL ENABLE CLINICAL INVESTIGATORS RELIABLY TO DETECT THE AMOUNTS OF SALIVARY, PANCREATIC, AND OVARIAN AMYLASES IN PATIENT SPECIMENS. IT IS ANTICIPATED THAT IT WILL BE POSSIBLE TO GENERATE MONOCLONALS WHICH WILL DETECT SPECIFIC ISOELECTRIC VARIANTS OF EACH ISOZYME. DURING PHASE I MONOCLONAL ANTIBODIES SPECIFIC FOR EACH ISOENZYME WILL BE GENERATED. THEY WILL FORM THE BASIS FOR KIT DEVELOPMENT AND CLINICAL TESTING DURING PHASE II. SUCH A KIT PERMITTING DIRECT EVALUATION OF AMYLASE ISOZYME LEVELS SHOULD PROVE SUPERIOR TO CURRENT METHODOLOGIES WHICH ARE EITHER TIME CONSUMING OR WHICH RELY ON INHIBITORS FOR DISTINGUSHING ISOZYMES. AT PRESENT ACTIVITY MEASUREMENTS CANNOT DISTINGUISH OVARIAN FROM SALIVARY ISOZYMES.

* Information listed above is at the time of submission. *

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