THE APPLICATION OF A IN VITRO MODEL SYSTEM FOR THE ISOLATION AND PROPAGATION OF CELLS HAVING SPECIFIC TUMOR PROPERTIES WILL BE DEMONSTRATED.

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1984
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
1400
Agency Tracking Number:
1400
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
4690 Hammermill Road, Atlanta, GA, 30084
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
PAUL J. PRICE
DIRECTOR
() -
Business Contact:
() -
Research Institute:
n/a
Abstract
THE APPLICATION OF A IN VITRO MODEL SYSTEM FOR THE ISOLATION AND PROPAGATION OF CELLS HAVING SPECIFIC TUMOR PROPERTIES WILL BE DEMONSTRATED. THE MODEL SYSTEM WILL ALSO BE UTILIZED TO TEST DIFFERENT MEDIA FORMULATIONS AS TO GENERAL APPLICABILITY FOR GROWING CARCINOMA CELLS IN VITRO. DURING PHASE I MONOCLONAL ANTIBODIES ALREADY DEVELOPED AGAINST SERIAL CELL LINES OF HUMAN PROSTATIC CARCINOMA CELLS WILL BE USED TO COAT STERILE POLYSTYRENE CELL CULTURE DISHES. FRESH PROSTATE TUMOR CELLS WILL BE COLLECTED, MINCED, AND MECHANICALLY OR ENZYMATICALLY SEPARATED AND PLATED ON SPECIFIC ANTIBODY COATED, NON-SPECIFIC ANTIBODY COATED AND CONTROL DISHES. CULTURES WILL BE GROWN AND PROPAGATED AND CHARACTERIZED AS TO ORIGIN AND TUMOR GENOTYPE. ATTEMPTS WILL BE MADE TO GROW THE ANTIBODY SELECTED CULTURES IN BULK. IN PARALLEL MONOCLONAL ANTIBODIES WILL BE INITIATED AGAINST HUMAN BREAST AND COLON CARCINOMA CELL LINES TO DEMONSTRATE IN PHASE II THE UTILITY AND SPECIFICITY OF THIS IN VITRO MODEL SYSTEM.

* information listed above is at the time of submission.

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