THE MEASUREMENT OF GLYCOSYLATED HEMOGLOBIN IS PROBABLY THE BEST MEANS OF ASSESSING GLUCOSE CONTROL OVER TIME IN DIABETICS.

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$48,741.00
Award Year:
1984
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
1375
Agency Tracking Number:
1375
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
4690 Hammermill Road, Atlanta, GA, 30084
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
DANIEL B. CAWLEY
RESEARCH SCIENTIST
() -
Business Contact:
() -
Research Institute:
n/a
Abstract
THE MEASUREMENT OF GLYCOSYLATED HEMOGLOBIN IS PROBABLY THE BEST MEANS OF ASSESSING GLUCOSE CONTROL OVER TIME IN DIABETICS. IT NOW APPEARS THERE IS INVERSE CORRELATION BETWEEN THE CONTROL OF GLUCOSE METABOLISM AND COMPLICATIONS OF THE DISEASE IN THAT WELL CONTROLLED DIABETICS DO MUCH BETTER. THE CURRENTLY AVAILABLE ASSAY SYSTEMS FOR QUANTITATING GLYCOSYLATED HEMOGLOBIN ARE BULKY, TIME CONSUMING AND EXPENSIVE AND THEREFORE ARE IDEAL CANDIDATES FOR REPLACEMENT WITH A MONOCLONAL ANTIBODY BASED IMMUNOASSAY. TO THAT END ANTIBODIES FROM HYBRIDOMA CLONES DERIVED FROM FUSIONS OF SPLEEN CELLS FROM MICE IMMUNIZED WITH THE GLYCOSYLATED HEMOGLOBIN ARE CURRENTLY BEING EVALUATED AND PLANS ARE TO DEVELOP ADDITIONAL HYBRIDOMAS AS PART OF PHASE I. DURING PHASE II A TWO-SITE IMMUNOMETRIC ASSAY WILL BE DEVELOPED FOR QUANTITATION OF GLYCOSYLATED HEMOGLOBIN FOR USE IN THE CLINICAL LABORATORY.

* information listed above is at the time of submission.

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