THE GLYCOPROTEIN HORMONE ERYTHROPOIETIN IS A PRIME REGULATOR OF RED CELL PRODUCTION IN HIGHER ORGANISMS.

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1985
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
3243
Agency Tracking Number:
3243
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
11040 Condor Ave., Fountain Valley, CA, 92708
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
DANIEL B. CAWLEY
PRINCIPAL INVESTIGATOR
(714) 546-9581
Business Contact:
() -
Research Institute:
n/a
Abstract
THE GLYCOPROTEIN HORMONE ERYTHROPOIETIN IS A PRIME REGULATOR OF RED CELL PRODUCTION IN HIGHER ORGANISMS. THE HORMONE IS PRODUCED IN THE KIDNEY IN RESPONSE TO HYPOXIA, FOR EXAMPLE, AS A RESULT OF ANEMIA. IT WOULD BE OF GREAT VALUE TO HAVE AN IMMUNOASSAY TO MONITOR ERYTHROPOIETIN LEVELS IN PEOPLE SUFFERING FROM ANEMIA, PULMONARY INSUFFICIENCY, RENAL TUMORS, ETC. AT PRESENT, ALTHOUGH BOTH MONOCLONAL ANTIBODIES AND POLYCLONAL ANTIBODIES HAVE BEEN RAISED TO ERYTHROPOIETIN, NO EFFICIENT IMMUNOASSAY BASED UPON THE (PREFERRED) MONOCLONAL ANTIBODY TECHNOLOGY HAS BEEN DEVELOPED. THE SPECIFIC AIM OF THIS PROPOSAL IS TO DEVELOP A PANEL OF MONOCLONAL ANTIBODIES TO ERYTHROPOIETIN, TO BE USED IN THE DESIGN OF AN IMMUNOASSAY APPROPRIATE TO THE CLINICAL LABORATORY.

* information listed above is at the time of submission.

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