STTR Phase I: Novel Materials for a PicoCalorimeter Biological Application

Award Information
Agency: National Science Foundation
Branch: N/A
Contract: 0930489
Agency Tracking Number: 0930489
Amount: $149,998.00
Phase: Phase I
Program: STTR
Awards Year: 2009
Solicitation Year: 2007
Solicitation Topic Code: MM
Solicitation Number: NSF 06-598
Small Business Information
HYPRES, Inc.
175 CLEARBROOK RD, ELMSFORD, NY, 10523
DUNS: 103734869
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Masoud Radparvar
 PhD
 (914) 592-1190
 masoud@hypres.com
Business Contact
 Masoud Radparvar
Title: PhD
Phone: (914) 592-1190
Email: masoud@hypres.com
Research Institution
 SUNY at Albany
 Michael Fancher
 255 Fuller Rd
Albany, NY, 12203 7514
 (518) 437-8686
 Nonprofit college or university
Abstract
This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). This Small Business Technology Transfer (STTR) Phase I project, a collaborative effort between HYRPES and the College of Nanoscale Science and Engineering of the University at Albany, NY, proposes to revolutionize the field of microcalorimetry with a micromachined biocalorimeter that is faster than conventional devices, more sensitive and inexpensive enough to be disposable. The device will feature one or more sample spaces etched into a silicon chip. Unlike earlier micromachined calorimeters, the high sensitivity is obtained in air, and without the need of a surrounding vacuum, making the new device ideal for studies of cellular metabolism. The overall research objectives are to introduce innovations that optimize and refine our ?PicoCalorimeter? designs to obtain <100 pico-Watt sensitivities in combination with other biological measurements. The broader impacts of this research are the measurement of cell metabolism, the identification of drug effects on specific cell types, and the study of protein folding, structural transitions and other biological phenomena. The proposed effort introduces a totally new type of microcalorimeter with a set of innovative features enabling measurements that are now impossible. The high sensitivity will enable the detection of much smaller sample volumes than ever before, thereby accelerating the time to prepare and investigate many biological reactions. Besides basic research in cellular metabolism, enzyme function, functional genomics, and others, the proposed disposable ""PicoCalorimeters"" will have a major commercial application to drug development and evaluation, and the detection of a wide range of toxins in liquid samples.

* information listed above is at the time of submission.

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