THE MECHANISMS OF WOUND HEALING AND TISSUE REPAIR IN HUMANS ARE OFTEN IMPAIRED IN THE ELDERLY, IN CANCER PATIENTS AFTER CHEMOTHERAPY AND RADIATION TREATMENTS, IN PERSONS WITH DIABETES OR POORLY HEALING FISTULAS, GHL-CU

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 2884
Amount: $50,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1985
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Iama, Inc.
15232 S.e. 48th Drive, Bellevue, WA, 98006
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 LOREN PICKART
 PRINCIPAL INVESTIGATOR
 (206) 641-9289
Business Contact
Phone: () -
Research Institution
N/A
Abstract
THE MECHANISMS OF WOUND HEALING AND TISSUE REPAIR IN HUMANS ARE OFTEN IMPAIRED IN THE ELDERLY, IN CANCER PATIENTS AFTER CHEMOTHERAPY AND RADIATION TREATMENTS, IN PERSONS WITH DIABETES OR POORLY HEALING FISTULAS, GHL-CU (GLYCYL-1-HISTIDYL-1-LYSINE:COPPER(II)) IS A GROWTH FACTOR PRESENT IN HUMAN BLOOD THAT APPEARS TO FUNCTION AS A WOUND-HEALING AND ANTITRAUMA HORMONE. GHL-CU ACCELERATES THE HEALING OF WOUNDS IN RATS, MICE, AND PIGS; POSSESSES ANTI-INFLAMMATORY ACTIVITIES; AND INDUCES NEW BLOOD VESSEL GROWTH. IN VITRO, GHL-CU IS A CHEMOATTRACTANT FOR CELLS ESSENTIAL IN HEALING SUCH AS MAST AND ENDOTHELIAL CELLS; INDUCES AXONAL AND DENDRITE OUTGROWTH FROM NEURONS; INHIBITS PLATELET AGGREGATION AND PRODUCTION OF THROMBOXANE. GHL-CU DISPLAYS SIGNIFICANT SUPEROXIDE DISMUTASE ACTIVITY, A BIOCHEMICAL ACTIVITY LINKED WITH ANTITRAUMA AND TISSUE-PROTECTIVE EFFECTS. WE PROPOSE TO DETERMINE 1.THE OPTIMAL DOSAGE OF GHL-CU AND TREATMENT SCHEDULES TO ENHANCE WOUND HEALING, 2.THE EFFECT OF GHL-CU CO-APPLIED WITH WOUND COVERAGE CREAMS AND3.WITH DIMETHYLSULFOXIDE, 4.THE RETENTION OF RADIOACTIVE GHL-CU IN TREATED WOUNDS, AND5.THE EFFECT ON WOUND HEALING OF TWO BIOACTIVE GHL-CU ANALOGS, N-OCTYL ESTER GLYCYL-1-HISTIDYL-1-LYSINE:COPPER(II) AND THIS WORK MAY LEAD TO THE DEVELOPMENT OF A NEW CLASS OF PHARMACEUTICALS FOR THE ACCELERATION OF WOUND HEALING.

* information listed above is at the time of submission.

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