NMR SENSORS FOR BIOREACTOR DIAGNOSTICS

Award Information
Agency:
National Science Foundation
Branch
n/a
Amount:
$50,000.00
Award Year:
1988
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Agency Tracking Number:
7523
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Intermagnetics General Corp
Po Box 566 Charles Park, Guilderland, NY, 12084
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
BRUCE E HAMMER PHD
() -
Business Contact:
() -
Research Institution:
n/a
Abstract
MONITORING THE INTERNAL ENVIRONMENT OF BIOCHEMICAL REACTION VESSELS IS CRUCIAL TO OPTIMIZING THE PERFORMANCE OF EXISTINGBIOREACTORS WHICH, IN TURN, CAN AID IN THE DESIGN AND EVALUATION OF FUTURE BIOREACTORS. THIS PROJECT PROPOSES TO NON-INVASIVELY MONITOR FLUID FLOW AND OXYGEN DISTRIBUTIONIN HOLLOW FIBER AND FLAT CELL BIOREACTORS BY NUCLEAR MAGNETIC RESONANCE (NMR) IMAGING TECHNIQUES. ANALYSIS OF BIOREACTOR INTERNAL STRUCTURE AND FLOW WILL BE MEASURED BY H-1 IMAGING AND FLOW IMAGING TECHNIQUES. SPATIAL MAPS OF OXYGEN CONCENTRATION WITHIN THE BIOREACTOR WILL BE DETERMINED BY F-19 T1 IMAGES. SUCCESSFUL COMPLETION OF THIS DEMONSTRATION OF PRINCIPLE WILL PROVIDE DETAILED KNOWLEDGE OF THE ULTIMATE USEFULNESS OF THE DEVICE AND TOGETHER WITH DESIGN DATA, IT WILL PROVIDENEEDED INFORMATION FOR THE DEVELOPMENT OF A PROTOTYPE NMR IMAGING/SPECTROSCOPY SYSTEM DURING PHASE II, IN ADVANCE OF COMMERCIALIZATION.

* information listed above is at the time of submission.

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