TWO-DIMENSIONAL ELECTROPHORESIS IS A POWERFUL TECHNIQUE, ALLOWING THE SEPARATION OF THOUSANDS OF PROTEINS IN A SINGLE ANALYSIS.

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$18,580.00
Award Year:
1985
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
3323
Agency Tracking Number:
3323
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
P.o. Box 2078, Corvallis, OR, 97339
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
GREGORY IDE
PRINCIPAL INVESTIGATOR
(507) 758-0999
Business Contact:
() -
Research Institute:
n/a
Abstract
TWO-DIMENSIONAL ELECTROPHORESIS IS A POWERFUL TECHNIQUE, ALLOWING THE SEPARATION OF THOUSANDS OF PROTEINS IN A SINGLE ANALYSIS. THE TECHNOLOGY HAS THE POTENTIAL TO BE DIAGNOSTIC FOR ALMOST ANY DISEASE STATE. UNFORTUNATELY, THE PRESENT TECHNOLOGY REQUIRES CONSIDERABLE EXPERTISE EXPERIMENTATION TO DESIGN PRE-CAST, INTEGRATED, TWO-DIMENSIONAL GELS WILL BE PERFORMED. PROTEIN SAMPLES FROM STIMULATED HUMAN LYMPHOCYTES WILL BE SEPARATED AND QUANTITATIVELY ANALYZED AS A TEST SYSTEM FOR THESE GELS. PHASE II EXPERIMENTATION WILL EXAMINE THE EFFICACY OF THESE THE RESEARCH WILL ALSO EXAMINE METHODS FOR PRODUCTION OF NARROW-RANGE, IMMOBILIZED PH GRADIENT ISOELECTRIC FOCUSING GELS. SEVERAL CHARGED DERIVATIVES OF ACRYLIC ACID WILL BE INVESTIGATED FOR THEIR ABILITY TO BE POLYMERIZED INTO POLYACRYLAMIDE GELS. IN PHASE II, THESE GELS WILL BE DESIGNED FOR SPECIFIC PH RANGES AND CLINICAL ASSAYS.

* information listed above is at the time of submission.

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