FTLV AS A SMALL LABORATORY MODEL OF HIV

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$475,455.00
Award Year:
1990
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Agency Tracking Number:
11056
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Idexx Corp.
100 Fore St, Portland, ME, 04101
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
() -
Business Contact:
() -
Research Institution:
n/a
Abstract
THE LONG-TERM OBJECTIVES OF THIS PROJECT ARE TO DEVELOP METHODOLOGIES AND A KNOWLEDGE BASE THAT WILL ENHANCE THE UTILIZATION OF FELINE T-CELL LYMPHOTROPIC LENTIVIRUS (FTLV) AS A SMALL-LABORATORY ANIMAL MODEL OF HIV. IN PHASE I, A FTLV ANTIGEN TEST WILL BE DEVELOPED THAT WILL AUGMENT EXISTING ANTIBODY TESTS AND PROVIDE VETERINARIANS AND RESEARCH SCIENTISTS WITH DIAGNOSTIC TOOLS TO MONITOR FTLV INFECTION. IT IS ALSO PLANNED TO BEGIN NUCLEIC ACID SEQUENCE ANALYSIS OF FTLV TO OBTAIN A BETTER UNDERSTANDING OF THE GENOMIC ORGANIZATION OF THIS VIRUS AND TO COMPARE THESE RESULTS WITHTHE KNOWN SEQUENCE OF HIV AND OTHER LENTIVIRUSES. THE FTLV MODEL POSSESSES ADVANTAGES FOR THE DEVELOPMENT OF DRUGS TO BLOCK LENTIVIRUS REPLICATION AND TO EVALUATE A PARTICULAR APPROACH IN THE DEVELOPMENT OF LENTIVIRUS VACCINES.

* information listed above is at the time of submission.

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