BETA-ENDORPHIN (BE) IS A PEPTIDE COMPOSED OF THE 30 CARBOXYL-TERMINAL RESIDUES OF BETA-LIPOTROPIN (BLPH).

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 3293
Amount: $47,736.00
Phase: Phase I
Program: SBIR
Awards Year: 1985
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
P.o. Box 7539, Columbia, MO, 65205
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 JOHN MCENTIRE
 PRINCIPAL INVESTIGATOR
 (314) 874-2481
Business Contact
Phone: () -
Research Institution
N/A
Abstract
BETA-ENDORPHIN (BE) IS A PEPTIDE COMPOSED OF THE 30 CARBOXYL-TERMINAL RESIDUES OF BETA-LIPOTROPIN (BLPH). IT HAS BEEN SHOWN TO BE A NATURALLY OCCURRING OPIATE, AS WELL AS TO POSSESS NONOPIATE RELATED BIOACTIVITY. CURRENT ASSAY TECHNIQUES ARE INADEQUATE DUE TO LACK OF IMMUNOLOGICAL SPECIFICITY RESULTING FROM CROSS-REACTING OF BE AND BLPH WITH THE SAME ANTIBODIES. A SEPARATION METHOD UTILIZING THE SELECTIVITY OF HPLC AND THE SENSITIVITY OF RIA HAS BEEN DEVELOPED, BUT IS LABORIOUS AND COSTLY. WE WILL ATTEMPT TO DEVELOP A SIMPLE, INEXPENSIVE ASSAY KIT BASED ON AN EXTRACTION METHOD USING DISPOSABLE SYRINGE CARTRIDGES AND QUANTITATION BY ELISA TECHNIQUES. THIS NEWLY DEVELOPED ASSAY WILL BE EVALUATED AGAINST THE EXISTING TECHNIQUES. PHASE II STUDIES WILL APPLY THIS NEWLY DEVELOPED ASSAY TO ESTABLISH THE RELATIONSHIP OF BE LEVELS TO MANAGEMENT OF CHRONIC PAIN IN THE CANCER PATIENT AND RHEUMATOID ARTHRITIS PATIENT.

* Information listed above is at the time of submission. *

Agency Micro-sites

SBA logo
Department of Agriculture logo
Department of Commerce logo
Department of Defense logo
Department of Education logo
Department of Energy logo
Department of Health and Human Services logo
Department of Homeland Security logo
Department of Transportation logo
Environmental Protection Agency logo
National Aeronautics and Space Administration logo
National Science Foundation logo
US Flag An Official Website of the United States Government