BETA-ENDORPHIN (BE) IS A PEPTIDE COMPOSED OF THE 30 CARBOXYL-TERMINAL RESIDUES OF BETA-LIPOTROPIN (BLPH).

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$47,736.00
Award Year:
1985
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
3293
Agency Tracking Number:
3293
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
P.o. Box 7539, Columbia, MO, 65205
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
JOHN MCENTIRE
PRINCIPAL INVESTIGATOR
(314) 874-2481
Business Contact:
() -
Research Institution:
n/a
Abstract
BETA-ENDORPHIN (BE) IS A PEPTIDE COMPOSED OF THE 30 CARBOXYL-TERMINAL RESIDUES OF BETA-LIPOTROPIN (BLPH). IT HAS BEEN SHOWN TO BE A NATURALLY OCCURRING OPIATE, AS WELL AS TO POSSESS NONOPIATE RELATED BIOACTIVITY. CURRENT ASSAY TECHNIQUES ARE INADEQUATE DUE TO LACK OF IMMUNOLOGICAL SPECIFICITY RESULTING FROM CROSS-REACTING OF BE AND BLPH WITH THE SAME ANTIBODIES. A SEPARATION METHOD UTILIZING THE SELECTIVITY OF HPLC AND THE SENSITIVITY OF RIA HAS BEEN DEVELOPED, BUT IS LABORIOUS AND COSTLY. WE WILL ATTEMPT TO DEVELOP A SIMPLE, INEXPENSIVE ASSAY KIT BASED ON AN EXTRACTION METHOD USING DISPOSABLE SYRINGE CARTRIDGES AND QUANTITATION BY ELISA TECHNIQUES. THIS NEWLY DEVELOPED ASSAY WILL BE EVALUATED AGAINST THE EXISTING TECHNIQUES. PHASE II STUDIES WILL APPLY THIS NEWLY DEVELOPED ASSAY TO ESTABLISH THE RELATIONSHIP OF BE LEVELS TO MANAGEMENT OF CHRONIC PAIN IN THE CANCER PATIENT AND RHEUMATOID ARTHRITIS PATIENT.

* information listed above is at the time of submission.

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