Photo-Linked Antibody Chelates for Tumor Imaging

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$75,000.00
Award Year:
1995
Program:
SBIR
Phase:
Phase I
Contract:
1 R43 CA65299-01A1,
Award Id:
29197
Agency Tracking Number:
29197
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
2134 Nicholasville Road, Suite, Lexington, KY, 40503
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Beby Jayaram
() -
Business Contact:
() -
Research Institution:
n/a
Abstract
Light induced chemical reactions (so-called photochemical activation) can be done under mild conditare physiological for biologically active macromolecules. We have recently used such photo-chemistryorganic molecules to antibodies. The photolinker contain side chains which can act as chelaters forproposal is to use this technique to produce radiolabeled antibodies for tumor imaging through photochelated 111Indium3+. Preliminary experiments showed that the photolinker attaches in a specific fason immunoglobulins of different isotopes and specificities. Furthermore, it was demonstrated that phretain the full capacity to bind to antigen. In the present proposal we plan to produce radiolabeledagainst a mouse and a human B cell lymphoma cell line and to use these radiolabeled antibodies to imscintigraphic techniques. We expect to show that our photoactivation technique will produce radiolabcancers with superior tumor-uptake specificity. Such radiolabeled antibodies are much needed and valdiagnosis and therapy.

* information listed above is at the time of submission.

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