Aromatic Dication Prodrugs for CNS Trypanosomiasis

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$107,000.00
Award Year:
2004
Program:
SBIR
Phase:
Phase I
Contract:
1R43AI061870-01
Award Id:
71265
Agency Tracking Number:
AI061870
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
IMMTECH INTERNATIONAL, INC., 150 FAIRWAY DR, STE 150, VERNON HILLS, IL, 60061
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
JAMES ALLEN
(847) 573-0033
JALLEN@IMMTECH.BIZ
Business Contact:
T THOMPSON
(847) 573-0033
STHOMPSON@IMMTECH.BIZ
Research Institution:
n/a
Abstract
DESCRIPTION (provided by applicant): The long-range research goal is to develop a new drug to treat secondary (central nervous system) stage human African trypanosomiasis. Previous SBIR supported research identified DB289, a methoxime prodrug of the aromatic dication furamidine, that is currently progressing in Phase lib clinical trials for treatment of early stage African sleeping sickness. DB289, however, is not curative in animal models of CNS stage trypanosomiasis. We have recently identified alkylamidoxime prodrugs of novel aza analogs of furamidine that are curative in a chronic mouse model of infection. The objective of this Phase I SBIR application is to synthesize sufficient quantities of six prodrugs to perform further efficacy, toxicity and metabolism studies. The specific aims are designed to permit selection of a lead candidate compound to enroll during Phase II research into advanced efficacy testing in a primate model of CNS infection and into formal preclinical toxicity testing. The research may lead to development of a potent, safe and economical new drug to treat this devastating protozoan parasitic infection currently estimated to be killing over 300,000 people in recent outbreaks in Africa.

* information listed above is at the time of submission.

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