BIOPROCESSING CELLS FROM BLOOD USING BR-FF AND HGMS

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1991
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Agency Tracking Number:
16697
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Immunicon Corpon
1310 Masons Mill Ii, Huntingdon Valley, PA, 19006
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Liberti, Paul A
Principal Investigator
(215) 938-0100
Business Contact:
1 R43 HL46073-01
() -
Research Institution:
n/a
Abstract
THE LONG TERM OBJECTIVE IS TO DEVELOP A NEW TECHNOLOGY FOR INDUSTRY SCALE AFFINITY SEPARATIONS EMPLOYING PROPRIETARY BIO-RECEPTOR FERROFLUIDS (BR-FF) IN COMBINATION WITH EXISTING CONTINUOUS HIGH GRADIENT MAGNETIC SEPARATORS (HGMS) AND IMPROVED SYSTEMS CURRENTLY BEING DEVELOPED. BR-FF ARE BEING USED WITH HGMS SUCCESSFULLY FOR DOING IMMUNOASSAYS AND TOGETHER THEY REPRESENT A SIGNIFICANT STEP FORWARD IN THE FIELD OFFERING NUMEROUS ADVANTAGES OVER PRIOR SYSTEMS. THE SPECIFIC AIMS ARE TO DETERMINE IF BR-FF AS CURRENTLY SYNTHESIZED OR AS SYNTHESIZED BY RELATIVELY STRAIGHTFORWARD MODIFICATION CAN WITHSTAND THE RIGORS OF DESORPTION (LOW PH, DENATURANTS, KAOTROPIC IONORS (HGMS) AND IMPROVED SYSTEMS CURRENTLY BEING DEVELOPED. BR-FF ARE BEING USED WITH HGMS SUCCESSFULLY FOR DOING IMMUNOASSAYS AND TOGETHER THEY REPRESENT A SIGNIFICANT STEP FORWARD IN THE FIELD OFFERING NUMEROUS ADVANTAGES OVER PRIOR SYSTEMS. THE SPECIFIC AIMS ARE TO DETERMINE IF BR-FF AS CURRENTLY SYNTHESIZED OR AS SYNTHESIZED BY RELATIVELY STRAIGHTFORWARD MODIFICATION CAN WITHSTAND THE RIGORS OF DESORPTION (LOW PH, DENATURANTS, KAOTROPIC IONS) AND RECYCLING. AFFINITY SEPARATIONS CURRENTLY PLAY A MINOR ROLE IN BIOPROCESSING IN PART BECAUSE OF COST AND THE NATURE OF AFFINITY SUPPORTS (PARTICLES OR MEMBRANES) WHICH ARE CONSTRAINED TO BATCH MODE AND ULTRA CLEAN SOLUTIONS. BR-FF AND HGMS OFFERS THE POTENTIAL FOR CONTINUOUS AFFINITY SEPARATION WHICH CAN FUNCTION IN THE PRESENCE OF MAJOR SOLUTION CONTAMINANTS INCLUDING SOLIDS; THUS A NEW BIOPROCESSING TECHNOLOGY WHICH ALSO REQUIRES SIGNIFICANTLY LESS PROCESSING STEPS IS POSSIBLE.

* information listed above is at the time of submission.

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