BIOPROCESSING CELLS FROM BLOOD USING BR-FF AND HGMS

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 16697
Amount: $50,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1991
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
1310 Masons Mill Ii, Huntingdon Valley, PA, 19006
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Liberti, Paul A
 Principal Investigator
 (215) 938-0100
Business Contact
 1 R43 HL46073-01
Phone: () -
Research Institution
N/A
Abstract
THE LONG TERM OBJECTIVE IS TO DEVELOP A NEW TECHNOLOGY FOR INDUSTRY SCALE AFFINITY SEPARATIONS EMPLOYING PROPRIETARY BIO-RECEPTOR FERROFLUIDS (BR-FF) IN COMBINATION WITH EXISTING CONTINUOUS HIGH GRADIENT MAGNETIC SEPARATORS (HGMS) AND IMPROVED SYSTEMS CURRENTLY BEING DEVELOPED. BR-FF ARE BEING USED WITH HGMS SUCCESSFULLY FOR DOING IMMUNOASSAYS AND TOGETHER THEY REPRESENT A SIGNIFICANT STEP FORWARD IN THE FIELD OFFERING NUMEROUS ADVANTAGES OVER PRIOR SYSTEMS. THE SPECIFIC AIMS ARE TO DETERMINE IF BR-FF AS CURRENTLY SYNTHESIZED OR AS SYNTHESIZED BY RELATIVELY STRAIGHTFORWARD MODIFICATION CAN WITHSTAND THE RIGORS OF DESORPTION (LOW PH, DENATURANTS, KAOTROPIC IONORS (HGMS) AND IMPROVED SYSTEMS CURRENTLY BEING DEVELOPED. BR-FF ARE BEING USED WITH HGMS SUCCESSFULLY FOR DOING IMMUNOASSAYS AND TOGETHER THEY REPRESENT A SIGNIFICANT STEP FORWARD IN THE FIELD OFFERING NUMEROUS ADVANTAGES OVER PRIOR SYSTEMS. THE SPECIFIC AIMS ARE TO DETERMINE IF BR-FF AS CURRENTLY SYNTHESIZED OR AS SYNTHESIZED BY RELATIVELY STRAIGHTFORWARD MODIFICATION CAN WITHSTAND THE RIGORS OF DESORPTION (LOW PH, DENATURANTS, KAOTROPIC IONS) AND RECYCLING. AFFINITY SEPARATIONS CURRENTLY PLAY A MINOR ROLE IN BIOPROCESSING IN PART BECAUSE OF COST AND THE NATURE OF AFFINITY SUPPORTS (PARTICLES OR MEMBRANES) WHICH ARE CONSTRAINED TO BATCH MODE AND ULTRA CLEAN SOLUTIONS. BR-FF AND HGMS OFFERS THE POTENTIAL FOR CONTINUOUS AFFINITY SEPARATION WHICH CAN FUNCTION IN THE PRESENCE OF MAJOR SOLUTION CONTAMINANTS INCLUDING SOLIDS; THUS A NEW BIOPROCESSING TECHNOLOGY WHICH ALSO REQUIRES SIGNIFICANTLY LESS PROCESSING STEPS IS POSSIBLE.

* Information listed above is at the time of submission. *

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