BIOPROCESSING CELLS FROM BLOOD USING BR-FF AND HGMS

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1991
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
16697
Agency Tracking Number:
16697
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
1310 Masons Mill Ii, Huntingdon Valley, PA, 19006
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Liberti, Paul A
Principal Investigator
(215) 938-0100
Business Contact:
1 R43 HL46073-01
() -
Research Institute:
n/a
Abstract
THE LONG TERM OBJECTIVE IS TO DEVELOP A NEW TECHNOLOGY FOR INDUSTRY SCALE AFFINITY SEPARATIONS EMPLOYING PROPRIETARY BIO-RECEPTOR FERROFLUIDS (BR-FF) IN COMBINATION WITH EXISTING CONTINUOUS HIGH GRADIENT MAGNETIC SEPARATORS (HGMS) AND IMPROVED SYSTEMS CURRENTLY BEING DEVELOPED. BR-FF ARE BEING USED WITH HGMS SUCCESSFULLY FOR DOING IMMUNOASSAYS AND TOGETHER THEY REPRESENT A SIGNIFICANT STEP FORWARD IN THE FIELD OFFERING NUMEROUS ADVANTAGES OVER PRIOR SYSTEMS. THE SPECIFIC AIMS ARE TO DETERMINE IF BR-FF AS CURRENTLY SYNTHESIZED OR AS SYNTHESIZED BY RELATIVELY STRAIGHTFORWARD MODIFICATION CAN WITHSTAND THE RIGORS OF DESORPTION (LOW PH, DENATURANTS, KAOTROPIC IONORS (HGMS) AND IMPROVED SYSTEMS CURRENTLY BEING DEVELOPED. BR-FF ARE BEING USED WITH HGMS SUCCESSFULLY FOR DOING IMMUNOASSAYS AND TOGETHER THEY REPRESENT A SIGNIFICANT STEP FORWARD IN THE FIELD OFFERING NUMEROUS ADVANTAGES OVER PRIOR SYSTEMS. THE SPECIFIC AIMS ARE TO DETERMINE IF BR-FF AS CURRENTLY SYNTHESIZED OR AS SYNTHESIZED BY RELATIVELY STRAIGHTFORWARD MODIFICATION CAN WITHSTAND THE RIGORS OF DESORPTION (LOW PH, DENATURANTS, KAOTROPIC IONS) AND RECYCLING. AFFINITY SEPARATIONS CURRENTLY PLAY A MINOR ROLE IN BIOPROCESSING IN PART BECAUSE OF COST AND THE NATURE OF AFFINITY SUPPORTS (PARTICLES OR MEMBRANES) WHICH ARE CONSTRAINED TO BATCH MODE AND ULTRA CLEAN SOLUTIONS. BR-FF AND HGMS OFFERS THE POTENTIAL FOR CONTINUOUS AFFINITY SEPARATION WHICH CAN FUNCTION IN THE PRESENCE OF MAJOR SOLUTION CONTAMINANTS INCLUDING SOLIDS; THUS A NEW BIOPROCESSING TECHNOLOGY WHICH ALSO REQUIRES SIGNIFICANTLY LESS PROCESSING STEPS IS POSSIBLE.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government