Analysis of Circulating Cancer Cells Early in Disease

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 2R44CA083598-02
Amount: $309,500.00
Phase: Phase II
Program: SBIR
Awards Year: 2001
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 () -
Business Contact
Phone: (215) 938-0100
Research Institution
DESCRIPTION: (provided by applicant) The long term objective of this proposal is commercialization of a test for the management of cancer. Immunicon has developed a sensitive test for detecting tumor cells in peripheral blood. This test uses ferrofluids and magnetic separation technology for tumor cell enrichment and multidimensional flow cytometry for cell analysis. Clinical data show that tumor cells exist in the blood of breast cancer patients. One limitation of this test is that flow cytometry does not confirm the identity of the events that are detected. Morphologic features of cells of immunophenotypically identified events can improve the specificity of the test. These features can be obtained using multicolor fluorescent microscopy. The quantity of ferrofluid used to capture tumor cells from blood, however, can obscure the cell. Phase I feasibility data show that proposed new methods helped to decrease ferrofluid without sacrificing the sensitivity of the test and the proposed objectives were achieved. Feasibility data also shows that incorporating these methods into new assay procedures permits microscopy analysis - a significant breakthrough. The aim of this Phase II proposal is to adapt these new procedures which incorporate the Phase I developments to further develop and validate the test to detect cancer cells present in blood using multi color fluorescent microscopy. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE

* Information listed above is at the time of submission. *

Agency Micro-sites

SBA logo
Department of Agriculture logo
Department of Commerce logo
Department of Defense logo
Department of Education logo
Department of Energy logo
Department of Health and Human Services logo
Department of Homeland Security logo
Department of Transportation logo
Environmental Protection Agency logo
National Aeronautics and Space Administration logo
National Science Foundation logo
US Flag An Official Website of the United States Government