THIS PROPOSAL IS FOR EXTENDING STUDIES RELATED TO THE EVALUATION OF POLYCATION HEXADIMETHRINE (HDM) AND ITS COMPONENTS AS ANTICANCER AGENTS.

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 455
Amount: $29,820.00
Phase: Phase I
Program: SBIR
Awards Year: 1983
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
The Arctic Bldg., 700 3rd Ave., Suite 840, Seattle, WA, 98104
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 LEONARD M. PRATT
 PRINCIPAL INVESTIGATOR
 (206) 583-6562
Business Contact
Phone: () -
Research Institution
N/A
Abstract
THIS PROPOSAL IS FOR EXTENDING STUDIES RELATED TO THE EVALUATION OF POLYCATION HEXADIMETHRINE (HDM) AND ITS COMPONENTS AS ANTICANCER AGENTS. THESE INVESTIGATORS HAVE DEMONSTRATED A DIFFERENTIAL EFFECT OF HDM ON MIXED LYMPHOCYTE CELL CULTURE (MLC) AND ON L1210 CELLS. AT THE DOSES WHICH INHIBIT (3)H-THYMIDINE INCORPORATION INTO L1210 CELLS BY 50 PERCENT, THE RESPONSE OF THE MLC WAS STIMULATED TWO-FOLD. SINCE HDM IS A HETEROGENEOUS MIXTURE OF DIFFERENT MOLECULAR WEIGHTS, THIS PROPOSAL IS FOR ISOLATION OF THE MOST ACTIVE MOLECULAR WEIGHT FRACTION AND ITS EVALUATION BOTH "IN VITRO" AND "IN VIVO", AGAINST L1210 AND P388 LEUKEMIAS AND ON MIXED LYMPHOCYTE CULTURE. RESOLUTION WILL BE ATTAINED BY SEPHADEX GEL FILTRATION CHROMATOGRAPHY AND THE ACTIVE FRACTION(S) WILL BE IDENTIFIEDIN "IN VITRO" CELL CULTURE ASSAYS. SINCE HDM COULD CAUSE MAST CELL DEGRANULATION, SOME OF THE ANTITUMOR EVALUATION STUDIES WILL BE CARRIED OUT IN CONJUNCTION WITH ANTIHISTAMINE THERAPY, ESSENTIALLY INVOLVING TREATMENT WITH BENZALKONIUN CHLORIDE OR DIPHENHYDRAMINE TYPE DRUGS.

* Information listed above is at the time of submission. *

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