THIS PROJECT WILL EVALUATE ANTIBODY-MEDIATED, POLYMER-BOUND YTTRIUM-90 AS A CANCER THERAPY AGENT.

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 3060
Amount: $50,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1985
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
100 Bergen Street Bldg. #5, Newark, NJ, 07103
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 GARY GRIFFITHS
 PRINCIPAL INVESTIGATOR
 (201) 456-4779
Business Contact
Phone: () -
Research Institution
N/A
Abstract
THIS PROJECT WILL EVALUATE ANTIBODY-MEDIATED, POLYMER-BOUND YTTRIUM-90 AS A CANCER THERAPY AGENT. ANTIBODIES WILL BE COUPLED THROUGH ONE COVALENT BOND TO A SMALL POLYLYSINE UNIT. THE LATTER WILL CARRY, VIA A BIFUNCTIONAL COUPLING AGENT, MOLECULES OF THE TRIVALENT METAL CHELATING SIDEROPHORE, DEFEROXAMINE. EACH DEFEROXAMINE WILL BE COMPLEXED WITH A SINGLE ATOM OF YTTRIUM-90, A HIGH ENERGY BETA-EMITTER. THE OPTIMUM NUMBER OF DEFEROXAMINES, BINDABLE TO THE EPSILON AMINO GROUPS WILL BE DETERMINED AND UNREACTED AMINO GROUPS BLOCKED TO ENSURE NONINTERFERENCE IN ANTIBODY CONJUGATION. THE POLYLYSINE-DEFEROXAMINE LINKER USED IN THIS LABORATORY HAS BEEN SHOWN TO WORK VERY WELL IN SIMILAR SYSTEMS, AND WILL BE APPLIED HERE. IN THE SCHEME WE PROPOSE WE HAVE TWO DISTINCT ROUTES FOR COUPLING POLYMER DOSIMETRY AND BIODISTRIBUTION ASPECTS WILL BE INVESTIGATED TO DETERMINE THE STABILITY OF OUR SYSTEM IN VIVO, TO EVALUATE DOSE DELIVERY TO TUMOR

* Information listed above is at the time of submission. *

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