THIS PROJECT IS CONCERNED WITH THE DEVELOPMENT OF NONENZYMATIC REAGENTS FOR IMMUNOHISTOCHEMISTRY, WITH EMPHASIS ON ADAPTING THE NEW TECHNOLOGY TO THE EXPANDING FIELD OF IMMUNOHISTOCHEMICAL DIAGNOSIS OF CANCER.

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 2984
Amount: $50,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1985
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
100 Bergen Street, Newark, NJ, 07103
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 DAN SHOCHAT
 PRINCIPAL INVESTIGATOR
 (201) 456-4779
Business Contact
Phone: () -
Research Institution
N/A
Abstract
THIS PROJECT IS CONCERNED WITH THE DEVELOPMENT OF NONENZYMATIC REAGENTS FOR IMMUNOHISTOCHEMISTRY, WITH EMPHASIS ON ADAPTING THE NEW TECHNOLOGY TO THE EXPANDING FIELD OF IMMUNOHISTOCHEMICAL DIAGNOSIS OF CANCER. PHASE I INVOLVES THE DEVELOPMENT OF THE FIRST FAMILY OF REAGENTS, NAMELY, PHENAZINE DERIVATIVES CONJUGATED TO ANTIBODIES AGAINST TUMOR-ASSOCIATED ANTIGENS, AND DETERMINATION OF STABILITY, IMMUNOREACTIVITY, AND STAINING OF TUMOR TISSUE SECTIONS. PHASE II WILL BE DEVOTED TO THE DEVELOPMENT OF STAINING PROTOCOLS AND KITS AND EXPLORATIONS OF NEW CLASSES OF STAINING REAGENTS, INCLUDING ARTIFICIAL ENZYMES AND IMPROVING THE CONJUGATION OF THESE LIGANDS TO THE ANTIBODIES (ESPECIALLY VIA BRIDGING SYNTHETIC POLYMERS). IT IS EXPECTED THAT THE NEW NONENZYMATIC REAGENTS WILL PROVE TO BE MORE STABLE THAN THE CONVENTIONAL ANTIBODY-ENZYME REAGENTS, THUS HAVING A LONGER SHELF LIFE, AND WILL BE

* Information listed above is at the time of submission. *

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