THIS PROJECT IS CONCERNED WITH THE DEVELOPMENT OF NONENZYMATIC REAGENTS FOR IMMUNOHISTOCHEMISTRY, WITH EMPHASIS ON ADAPTING THE NEW TECHNOLOGY TO THE EXPANDING FIELD OF IMMUNOHISTOCHEMICAL DIAGNOSIS OF CANCER.

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1985
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
2984
Agency Tracking Number:
2984
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
100 Bergen Street, Newark, NJ, 07103
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
DAN SHOCHAT
PRINCIPAL INVESTIGATOR
(201) 456-4779
Business Contact:
() -
Research Institute:
n/a
Abstract
THIS PROJECT IS CONCERNED WITH THE DEVELOPMENT OF NONENZYMATIC REAGENTS FOR IMMUNOHISTOCHEMISTRY, WITH EMPHASIS ON ADAPTING THE NEW TECHNOLOGY TO THE EXPANDING FIELD OF IMMUNOHISTOCHEMICAL DIAGNOSIS OF CANCER. PHASE I INVOLVES THE DEVELOPMENT OF THE FIRST FAMILY OF REAGENTS, NAMELY, PHENAZINE DERIVATIVES CONJUGATED TO ANTIBODIES AGAINST TUMOR-ASSOCIATED ANTIGENS, AND DETERMINATION OF STABILITY, IMMUNOREACTIVITY, AND STAINING OF TUMOR TISSUE SECTIONS. PHASE II WILL BE DEVOTED TO THE DEVELOPMENT OF STAINING PROTOCOLS AND KITS AND EXPLORATIONS OF NEW CLASSES OF STAINING REAGENTS, INCLUDING ARTIFICIAL ENZYMES AND IMPROVING THE CONJUGATION OF THESE LIGANDS TO THE ANTIBODIES (ESPECIALLY VIA BRIDGING SYNTHETIC POLYMERS). IT IS EXPECTED THAT THE NEW NONENZYMATIC REAGENTS WILL PROVE TO BE MORE STABLE THAN THE CONVENTIONAL ANTIBODY-ENZYME REAGENTS, THUS HAVING A LONGER SHELF LIFE, AND WILL BE

* information listed above is at the time of submission.

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