THE AIM OF THIS PHASE I PROJECT IS TO DEVELOP NOVEL ANTIBODYCONJUGATES FOR USE IN THE RADIOIMMUNODETECTION OF TUMORS.

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1986
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
4743
Agency Tracking Number:
4743
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
5 Bruce Street, Building 5, Newark, NJ, 07103
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
GARY L GRIFFITHS
PRINCIPAL INVESTIGATOR
(201) 456-4779
Business Contact:
() -
Research Institute:
n/a
Abstract
THE AIM OF THIS PHASE I PROJECT IS TO DEVELOP NOVEL ANTIBODYCONJUGATES FOR USE IN THE RADIOIMMUNODETECTION OF TUMORS. IN RESPONSE TO THE PROBLEMS ASSOCIATED WITH THE ANTIBODY- DTPA-RADIOMETAL IMAGING METHODOLOGIES WITH REGARD TO LIVER DEPOSITION OF THE METAL, A NUMBER OF MORE SPECIFIC CHELATORSWILL BE INVESTIGATED. BASED ON THE CAPABILITY OF THE CHELATORS TO TIGHTLY BIND THE METAL AND BECAUSE OF THEIR GREATER LIPOPHILIC CHARACTER AND LACK OF EXCESS FUNCTIONALITY, ENHANCEMENT OF MEMBRANE TRANSPORT OF THE LIGAND-METAL COMPLEX IS TO BE EXPECTED. THE OVERALL SYNTHETIC STRATEGY WILL ALLOW A LARGE NUMBER OF ALTERNATIVESTO BE CONSIDERED IN THE FUTURE, WHILE THE COMPOUNDS' CLOSE CORRELATION WITH UBIQUITOUS NATURAL PRODUCTS WOULD NOT INDICATE ANY FUTURE CYTOTOXIC PROBLEMS. ANTIBODY CONJUGATION WILL FOLLOW PROTOCOLS ESTABLISHED IN THESE LABORATORIES AND ELSEWHERE.

* information listed above is at the time of submission.

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