THE PRODUCTION OF 188 RE-LABELED MONOCLONAL ANTIBODIES

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1992
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
18988
Agency Tracking Number:
18988
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
300 American Road, Morris Plains, NJ, 07950
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Gary L Griffiths
(201) 456-4779
Business Contact:
() -
Research Institution:
n/a
Abstract
THE AIM OF THIS PROJECT IS TO ULTIMATELY DEVELOP NOVEL THERAPEUTIC AGENTS FOR THE TREATMENT OF CANCER. THE AGENTS ARE BASED ON THE USE OF RADIOLABELED MONOCLONAL ANTIBODY BEARING THE ISOTOPE, RHENIUM-188. THIS ISOTOPE IS A GENERATOR PRODUCED ITEM WHICH COULD BE USED IN ANY NUCLEAR PHARMACY IN A RAPID MANNER TO GIVE INJECTABLE MATERIAL, AND CARRYING A GAMMA EMISSION AS WELL AS A BETA EMISSION CAN BE USED AS A VISUALIZING AGENT ON SPECT. ANTIBODIES WILL BE LABELED WITH THIS ISOTOPE USING DIRECT LABELING TECHNOLOGY AND TESTED FOR EFFICACY IN SUITABLE ANIMAL MODELS. THE MOST EFFECTIVE FORMAT FOR RHENIUM ANTIBODY WILL BE DETERMINED BY THESE STUDIES, PRIOR TO PHASE II WORK ON DOSE ESCALATION AND TOLERABILITY FOLLOWED BY INITIAL CLINICAL STUDIES. DEVELOPMENT WORK ON THE PRODUCT(S) WILL BE CARRIED OUT IN THE SECOND PHASE GIVEN GOOD CLINICAL RESULTS, AND AT THE END OF PHASE II, MULTI-CENTER CLINICAL TRIALS AND A PHASE III IND ARE TO BE EXPECTED. IT IS ENVISAGED THAT THE PRODUCTS FINAL DESIGN WILL BE SIMPLE ENOUGH TO ALLOW ON-SITE ONE-STEP RADIOLABELING A TRAINED NUCLEAR MEDICINE TECHNOLOGISTS, WITH THE MINIMUM OF ANALYTICAL VALIDATION, AND THEN BE READY FOR IMMEDIATE PATIENT USE.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government