A Multiplexed Point-of-Care Assay for the Detection of Enteric Pathogens that Cause Severe Diarrhea in Deployed Soldiers

Award Information
Agency:
Department of Defense
Branch
Army
Amount:
$69,798.00
Award Year:
2006
Program:
SBIR
Phase:
Phase I
Contract:
W81XWH-07-C-0030
Agency Tracking Number:
A062-158-0254
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
INBIOS INTERNATIONAL
562 Ist Ave S, Suite 600, Seattle, WA, 98104
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
004006628
Principal Investigator:
William MORROW
Principal Investigator
(206) 344-5821
wjwmorrow@inbios.com
Business Contact:
Estela FIGUEROA
President
(206) 344-5821
inbios@aol.com
Research Institution:
n/a
Abstract
The objective of this study is to develop a robust, field-grade, screening assay for the detection of severe diarrheal disease-causing pathogens including E. coli O157, Salmonella spp., Shigella spp., Cryptosporidium spp., Campylobacter spp., Noroviruses, and Rotaviruses. The test will utilize lateral flow (dipstick) chromatography incorporated into a unique, multiplex cassette that enables the simultaneous screening of multiple analytes. The proposed immunochromatographic assay would be a very useful rapid screening test to assess individuals presenting with diarrhea of likely infectious etiology. In this Phase 1 study we shall evaluate the ability of a panel of antibodies, with specificity for the families of enteric pathogens listed above, to function as the basis of an antigen-capture detection system. We will then construct prototype assays that will be evaluated against samples from individuals with confirmed infections. Further development of the assay would take place in a Phase 2 proposal.

* information listed above is at the time of submission.

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