Development of a multiplexed point-of-care assay for the detection of infectious agents causing fever in deployed soldiers.

Award Information
Agency:
Department of Defense
Branch
Army
Amount:
$99,964.00
Award Year:
2005
Program:
SBIR
Phase:
Phase I
Contract:
W81XWH-06-C-0095
Agency Tracking Number:
O052-H07-3010
Solicitation Year:
2005
Solicitation Topic Code:
OSD05-H07
Solicitation Number:
2005.2
Small Business Information
INBIOS INTERNATIONAL
562 Ist Ave S, Suite 600, Seattle, WA, 98104
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
Y
Duns:
004006628
Principal Investigator:
Syamal Raychaudhuri
Chief Scientific Officer
(206) 344-5821
raychaud@inbios.com
Business Contact:
Estela Figueroa
President
(206) 344-5821
inbios@aol.com
Research Institution:
n/a
Abstract
This objective of this study is to develop a robust, field-grade, screening assay for the detection of fever-causing pathogens including Plasmodium sp., Salmonella, Rickettsial sp., Flaviviruses and Leptospira. The test will utilize lateral flow (dipstick) chromatography incorporated into a unique, multiplex, cassette that enables the simultaneous screening of multiple analytes. The proposed immunochromatographic assay would be a very useful rapid screening test to assess individuals presenting with fevers of likely infectious etiology. In this Phase 1 study we shall evaluate the ability of a panel of antigens, derived from the families of pathogens listed above, to function as the basis of a serological detection system. We will then construct a prototype assay that will be evaluated against sera from individuals with confirmed infections. Further development of the assay would take place in a Phase 2 proposal.

* information listed above is at the time of submission.

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