Antigen Detection Assay for Tuberculosis

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R41AI068291-01A1
Agency Tracking Number: AI068291
Amount: $386,997.00
Phase: Phase I
Program: STTR
Awards Year: 2006
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
562 1ST AVE. SOUTH, SUITE 600, SEATTLE, WA, 98104
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 (617) 892-8393
Business Contact
Phone: (206) 344-5821
Research Institution
BOSTON, MA, 02115
 Domestic nonprofit research organization
DESCRIPTION (provided by applicant): Antigen detection assay in contrast to conventional serological test, detects disease status and not the host antibody response to the disease etiological agent. It can therefore be used for both diagnosis and disease treatment follow-up purposes. Antigen detection assay has recently been successfully introduced for the diagnosis of different infectious diseases including hepatitis, pneumonia caused by Streptococcus pneumoniae or Legionella pneumophilla, sore throat cause by Streptococcus pyogenes, and amoebiasis. Although antigen detection assay has the potential to discriminate latent from adult tuberculosis, paradoxically this test has not yet been developed for this disease. Using the ultra-sensitive mass spectrometry technology we have recently described the presence of M. tuberculosis proteins in urine of infected mice. The proteins were sequenced, the encoding genes were cloned, and the recombinant proteins were obtained. One such molecule revealed to be a promising tool for the diagnosis of tuberculosis. Using similar approach we have recently identified M. tuberculosis antigens in urine of human patients with pulmonary tuberculosis. The present project aims to produce the corresponding recombinant proteins and use them as well as the ones previously described in mouse model to develop antigen detection assays for the diagnosis of tuberculosis disease.

* Information listed above is at the time of submission. *

Agency Micro-sites

SBA logo
Department of Agriculture logo
Department of Commerce logo
Department of Defense logo
Department of Education logo
Department of Energy logo
Department of Health and Human Services logo
Department of Homeland Security logo
Department of Transportation logo
Environmental Protection Agency logo
National Aeronautics and Space Administration logo
National Science Foundation logo
US Flag An Official Website of the United States Government