Combination Treatment of tPA and Apyrase for Stroke

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 2R44NS060175-02A1
Agency Tracking Number: NS060175
Amount: $1,107,150.00
Phase: Phase II
Program: SBIR
Awards Year: 2010
Solicitation Year: 2010
Solicitation Topic Code: NINDS
Solicitation Number: PHS2010-2
Small Business Information
APT THERAPEUTICS, INC., 4041 Forest Park Avenue, SAINT LOUIS, MO, -
DUNS: 192266141
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 RIDONG CHEN
 (312) 339-8455
 RCHEN@APT-THERAPEUTICS.COM
Business Contact
 RIDONG CHEN
Phone: (312) 339-8455
Email: rchen@apt-therapeutics.com
Research Institution
N/A
Abstract
DESCRIPTION (provided by applicant): Human apyrase represents a highly promising therapy for acute ischemic stroke which is a leading cause of death and disability with almost no effective therapy for most patients. Using a protein informatics approach, we have successfully engineered a human apyrase which exhibits significantly higher enzymatic activity and platelet inhibition than the wild-type apyrases. Importantly, the optimized apyrase conferred cerebroprotection against experimental stroke while preventing intracerebral hemorrhage. With the Phase II grant support, we will determine whether apyrase therapy is more effective while having lower bleeding risk than aspirin and a GPIIb/IIIa receptor antagonist, in combination with r-tPA for thrombolysis of stroke occlusion. PUBLIC HEALTH RELEVANCE: We will utilize clinically relevant embolic stroke models in rats to validate whether human apyrase improves efficacy and reduce cerebral hemorrhage associated with thrombolytic treatment of ischemic stroke.

* Information listed above is at the time of submission. *

Agency Micro-sites

SBA logo
Department of Agriculture logo
Department of Commerce logo
Department of Defense logo
Department of Education logo
Department of Energy logo
Department of Health and Human Services logo
Department of Homeland Security logo
Department of Transportation logo
Environmental Protection Agency logo
National Aeronautics and Space Administration logo
National Science Foundation logo
US Flag An Official Website of the United States Government