Advanced Detection Technologies for Biochips

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$932,297.00
Award Year:
2004
Program:
STTR
Phase:
Phase I
Contract:
1R41AI060057-01
Award Id:
71224
Agency Tracking Number:
AI060057
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
2100 Central Ave, Suite 106, BOULDER, CO, 80301
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
KATHY ROWLEN
(303) 449-8146
rowlen2@colorado.edu
Business Contact:
(303) 402-9100
Research Institute:
UNIVERSITY OF COLORADO AT BOULDER

UNIVERSITY OF COLORADO BOULDER
Boulder, CO, 80309

Nonprofit college or university
Abstract
DESCRIPTION (provided by applicant): The long-term objective of the proposed work is the development of innovative detection technologies for biochips (a.k.a. DNA microarrays). It is envisioned that the proposed technologies will enable the application of biochips to biodefense, particularly when a rapid and reliable diagnostic screen is required in the field. The Specific Aims of the proposed work are 1) development of an on-chip signal amplification technique that does not require enzymes, and 2) development of an inexpensive field-portable microarray reader to be used in combination with on-chip amplification. In order to focus initial efforts we have chosen to work in conjunction with NIH funded scientists who are developing a specific application, an influenza A biochip. Because influenza A is an easily transmitted, primarily airborne pathogen, and because this virus can be genetically engineered into novel forms, it represents a serious biodefense concern. In addition, the influenza A virus has a significant impact on human health, with an estimated 500,000 and 1,000,000 deaths worldwide each year, and worldwide surveillance is essential. Finally, influenza A can serve as an excellent model system for development and thorough testing of on-chip signal amplification and a field portable microarray reader.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government