Development of In Vivo EPR Tooth Dosimetry for Use by Non-Expert Personnel

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$600,000.00
Award Year:
2009
Program:
SBIR
Phase:
Phase I
Contract:
1R43AI081495-01A1
Award Id:
93386
Agency Tracking Number:
AI081495
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
278 RIVER ROAD, LYME, NH, 03768
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
809752756
Principal Investigator:
OLEG GRINBERG
(603) 650-1806
OLEG.GRINBERG@DARTMOUTH.EDU
Business Contact:
SWARTX
() -
clin.epr_hms@yahoo.com
Research Institution:
n/a
Abstract
DESCRIPTION (provided by applicant): The aim of the proposed project is to establish the feasibility of developing the techniques and the instrumentation that will enable EPR dosimetry, based on measurements of teeth in vivo, to be at a state where it can be used by non-expert personnel in the field in response to radiation events where large numbers of people have potentially had significant exposures to ionizing radiation. Ongoing studies at Dartmouth have demonstrated the safety of EPR tooth dosimetr y and its ability to quantify individual exposures to ionizing radiation. However, the devices currently in use are typical of laboratory equipment, requiring expert operators and a complicated, multi-step measurement and analysis process. In addition ther e have not been systematic studies of variables that are likely to affect measurements in real populations under field conditions such as tooth size and shape, the impact of significant dental work, and demographic differences (such as age, gender, race). To show the feasibility of EPR tooth dosimetry with non-expert users under practical field conditions, the study will: (i) develop hardware and software solutions automating the measurement process; (ii) develop experimental data on the impact of individua l differences; and (iii) develop sophisticated sampling and modeling techniques to account for individual differences. The studies will be carried out in collaboration with the Dartmouth EPR Center where, under a subcontract, the unique equipment and exper ience at Dartmouth will be used to develop experimental data that can be used to account for individual variations; advise on the development of modeling and software to account for individual variations, including testing software models developed by Clin -EPR; to consult on the development of hardware solutions for automating and simplifying measurement processes; and in conjunction with Clin-EPR to implement and test these hardware solutions. Achievement of these goals will enable a second phase of the pr oject in which we will produce a fully functional prototype instrument with capabilities and procedures that will be suitable for operation under field conditions by non-expert operators to assist in the triage of populations that have potentially been exp osed to clinically significant amounts of ionizing radiation. Such an instrument could then be prepared in an appropriate form for widespread use to enhance the effectiveness of responses to events in which large numbers of individuals have potentially bee n exposed to radiation. PUBLIC HEALTH RELEVANCE: The ability to measure individual radiation exposures of people at the site of a recent accident or terrorist event will be a major improvement in the capabilities of the emergency response system to react e ffectively to the medical challenges created by the potential exposure of large numbers of people to clinically significant levels of ionizing radiation. With the capability of EPR tooth dosimetry to provide after-the-fact estimates of doses to individuals , the medical assets available can be utilized most effectively by identifying those who do not need immediate entry into the health care system and those for whom appropriate and prompt intervention can increase the probability of reducing morbidity and m ortality from the exposure to radiation.

* information listed above is at the time of submission.

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