MEMS valve for an Intraurethral Continence Prosthesis

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 2R44DK057343-02
Agency Tracking Number: DK057343
Amount: $986,174.00
Phase: Phase II
Program: SBIR
Awards Year: 2003
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
INFINITE BIOMEDICAL TECHNOLOGIES, LLC
INFINITE BIOMEDICAL TECHNOLOGIES, LLC, 2850 N CHARLES ST, STE 100, BALTIMORE, MD, 21218
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 ANANTH NATARAJAN
 (626) 284-0077
 ananth@i-biomed.com
Business Contact
 ANANTH NATARAJAN
Phone: (410) 889-8011
Email: ANANTH@I-BIOMED.COM
Research Institution
N/A
Abstract
DESCRIPTION (provided by applicant): Urinary incontinence affects 15 - 35% of adult American women and accounts for a direct health care cost of over $26 Billion per year. It is associated with deterioration in quality of life and causes significant concern to many women. Current surgical therapies have significant morbidity associated with them. Therefore, a minimally invasive, nonsurgical treatment would be a great solution. We propose to address this challenge using microelectromechanical systems (MEMS) technology to develop a valve suitable for use in an artificial urethral sphincter. The Intraurethral Continence Prosthesis (INCOPRO) will use an innovative sphincter design based on biomimetic polymer technology to control urine flow. During Phase I, we successfully obtained proof-of-concept of the polypyrrole valve mechanism including testing in human urine. Further, we demonstrated micro-miniaturization using a MEMS fabrication process. In Phase II, we propose to further this work by developing a matrix of microvalves, which serves as a functional sphincter. We aim to extensively test the performance of the valve in vitro in a phantom model and further evaluate it in vivo in a porcine model. It is our long-term goal to incorporate this technology into a miniature device suitable for use in patients suffering from the debilitating problem of stress incontinence.

* information listed above is at the time of submission.

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