qEP Analysis of Comatose Patients: Mutal Synchronicity

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$184,972.00
Award Year:
2004
Program:
SBIR
Phase:
Phase I
Contract:
1R43HL076991-01
Agency Tracking Number:
HL076991
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
INFINITE BIOMEDICAL TECHNOLOGIES, LLC
INFINITE BIOMEDICAL TECHNOLOGIES, LLC, 3600 CLIPPER MILL ROAD #410, BALTIMORE, MD, 21211
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
HONGXUAN ZHANG
(410) 889-8011
HONGXUAN@I-BIOMED.COM
Business Contact:
JEFFREY WALLACE
(410) 889-8011
jeff@i-biomed.com
Research Institution:
n/a
Abstract
DESCRIPTION (provided by applicant): It is estimated that approximately 250,000-300,000 people experience cardiopulmonary arrest (CPA) each year in the United States. Approximately 80% of resuscitated patients remain in a coma for some time. Despite modern day healthcare efforts, many of these patients will not awaken. In such cases, caregivers are confronted with the difficult choice of continuing aggressive therapy or withdrawing life support. In evaluating the overall clinical picture of these comatose patients, Evoked Potentials (EP) may provide useful adjunct feedback on brain function. Thus we propose a Phase I effort to develop quantitative EP (qEP) analysis techniques for evaluation of comatose patients. Specifically, we propose Mutual Synchronicity (MS) as a method to combine aspects of amplitude and latency analysis into a unifying measure of brain injury. The goals of our Phase I study are 1) to develop Mutual Synchronicity (MS) based on advanced signal processing theory for objectively characterizing cortical and brainstem electrical activity, and 2) to test MS in a preliminary evaluation of comatose patients during post-CPA recovery. In the long-term, we plan to investigate the use of this technology as a bedside tool for monitoring the progression of coma after CPA.

* information listed above is at the time of submission.

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