Semantic Data Integration for Integrative Cancer Biology Research

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$1,390,541.00
Award Year:
2009
Program:
SBIR
Phase:
Phase II
Contract:
2R44CA132293-02A2
Award Id:
85489
Agency Tracking Number:
CA132293
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
INFOTECH SOFT, INC., 1201 Brickell Ave, MIAMI, FL, -
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
035354070
Principal Investigator:
MANSUR KABUKA
(305) 371-5111
KABUKA@INFOTECHSOFT.COM
Business Contact:
MANSUR KABUKA
() -
kabuka@infotechsoft.com
Research Institution:
n/a
Abstract
DESCRIPTION (provided by applicant): Recent advances in high-throughput measurements of critical parameters related to cancer genesis and development have led to a wealth of cancer-related information available in public and private databases. To realize t he promise of dramatic advancement in integrative cancer research enabled by this rapidly expanding information, novel informatics tools that allow researchers to efficiently integrate this available data are needed. The main objective of this proposal is to enable enhanced understanding and modeling of cancer processes through the development of the Cancer Biology Data Integration (CBDI) System, a collection of caGrid services and grid client applications capable of integrating data and information from di sparate sources. The CBDI System aims to exploit the rich semantic metadata information and the robust data exchange standards established through the Cancer Biomedical Informatics Grid (caBIG) Initiative, enhancing its use through the provision of a coher ent ontological view of caBIG semantics, so that data sources can be queried using a standard semantic query language. The CBDI System contains an Ontology View Generator to expose caBIG semantics using the Web Ontology Language (OWL) and a distributed Sem antic Query Processor that implements the semCDI query model to execute RDF-based queries using SPARQL against caGrid data services. The CBDI System also enables the integration of local private data collected by investigators and research institutions. An intuitive user interface providing multiple visualization and concept searching abilities is used to build queries and view results. In Phase I of the CBDI project, key algorithms and mechanisms of the CBDI System were developed, including the exposure of ontology views and the conversion of queries from SPARQL into caBIG's common query language. In addition the overall feasibility of the CBDI System was demonstrated with proof-of-concept prototypes of system components. During Phase II, the complete CBDI System will be implemented and tested with caBIG data services at six research institutions, evaluating its use in a variety of real-world operating conditions and functional scenarios. PUBLIC HEALTH RELEVANCE: The Cancer Biology Data Integration System is a collection of caBIG-compatible services that formulate a coherent ontological view of caBIG semantics so that ontology-based queries can be performed using the SPARQL query language over distributed caBIG-compatible data services.

* information listed above is at the time of submission.

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