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Optimized Platforms for Proper Glycosylation and Sialylation of Recombinant Human Butyrylcholinesterase (rBChE)
Title: Principal Investigator
Phone: (801) 915-7973
Phone: (801) 953-1047
The threat of organophosphate (OP) chemical warfare agents (CWA) to United States military personnel is a persistent problem due to the relative ease of manufacturing chemical threats compared to nuclear and biological agents. Human butyrylcholinesterase (BChE) has been identified as a probable bio-scavenger of OP CWAs that could be used to protect individuals that could be exposed to OP CWAs. The goal of this project is to generate a mammalian cell line capable of expressing human BChE in tetrameric form with appropriate human glycosylation patterns . To achieve this goal we will utilize a triple pronged approach with multiple cell lines currently used to produce human therapeutic proteins. Each approach will be evaluated to determine technical and economic applicability to full scale manufacturing.
* Information listed above is at the time of submission. *