Miniature EEG Telemetry Device for Translational Epilepsy Research

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$699,956.00
Award Year:
2009
Program:
SBIR
Phase:
Phase I
Contract:
1R43NS064661-01A2
Award Id:
94057
Agency Tracking Number:
NS064661
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
EPITEL, INC., 615 ARAPEEN DR, STE 310, SALT LAKE CITY, UT, 84108
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
808401157
Principal Investigator:
MARKLEHMKUHLE
() -
Business Contact:
DANUTAPETELENX
() -
Research Institute:
n/a
Abstract
DESCRIPTION (provided by applicant): Long-term continuous recording of electrical events from animal models of neurological disease is a critical component of translational research aimed at developing new therapies for debilitating disorders, such as epi lepsy. Recordings of the electroencephalogram (EEG) can be obtained for weeks or months at a time from adult rats with either tethered (i.e., wired ) or telemetric (i.e., wireless ) recording systems; however, both of these systems have problems. The pro posed studies will further develop and validate a miniature telemetry system (i.e., the EpiTel device) that will be optimized to record continuous (i.e., virtually uninterrupted) electrographic activity from rodent models of neurological disorders, such as intractable epilepsy. The fundamental principle of the EpiTel device is that a small self-contained telemetry unit with easily replaceable and inexpensive batteries is secured to the rodent's head. If this unit is damaged, it can be readily replaced. A pr ovisional patent for the EpiTel device has been submitted. The proposed experiments will use animal models of acquired epilepsy, and will aim to obtain stable long-term continuous recordings from adult rats and mice with convulsive seizures. The long-term goal is for researchers to be able to use the EpiTel device in translational research to develop new therapies for different types of animal models of acquired epilepsy. We have preliminary proof-of-principle data, but aim to test the newly-developed Epi Tel device in rat and mouse models of epilepsy. The goal in Phase I is to show that it is feasible to obtain long-term continuous recordings (i.e., for many months at a time). Ultimately, the EpiTel device could also be adapted to immature rats in order to allow studies of pediatric epilepsy. These experiments will allow better validation of animal models of epilepsy and other neurological disorders. The ability to obtain long-term continuous recordings should facilitate the development of new therapies to suppress epileptic seizures and potentially to block the development of chronic epilepsy after brain injury. PUBLIC HEALTH RELEVANCE: This grant proposal aims to develop and validate a new miniature telemetry system for rats and mice that should facilitate translational research on animal models of epilepsy.

* information listed above is at the time of submission.

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